Birthweight and body mass index in young adulthood: the Swedish young male twins study.
Birthweight and body mass index in young adulthood: the Swedish young male twins study.
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DOI：
10.1375/twin.4.5.400
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发表时间：
2001-10-01
期刊：
影响因子：
--
通讯作者：
Rasmussen, F
中科院分区：
文献类型：
--
作者：
Johansson, M;Rasmussen, F
许多研究发现，胎儿发育与与成年代谢综合征相关的心血管疾病之间存在负相关。然而，遗传学和宫内环境的相对重要性仍然不清楚。这项研究的目的是通过研究胎儿生长对青壮年体重指数(BMI)的影响来检验胎儿起源假说和胎儿胰岛素抵抗假说。在一项全国性的队列研究中，将1973-1979年瑞典医疗出生登记簿与1990-1999年兵役征兵登记簿联系起来。1998年，向这两个登记册中包括的所有在世且仍居住在瑞典的双胞胎男婴邮寄了一份调查问卷。这项研究涵盖了923对有完整数据的男性双胞胎。混合线性模型被用来估计出生体重的配对内和配对间差异及其与BMI的关系。在同卵双胞胎中发现与出生体重和体重指数不同的弱正相关。出生体重和BMI之间的配对差异在单合子之间没有发现明显的关联。未发现同卵双胞胎有显著关联。这些发现似乎既不支持胎儿程序化假说，也不支持胎儿胰岛素抵抗假说。
Many studies have found an inverse association between fetal growth and cardiovascular disease related to the metabolic syndrome in adulthood. Nevertheless, the relative importance of genetics and the intrauterine environment remain unclear. The objective of the study was to test the fetal origins hypothesis and the fetal insulin resistance hypothesis by studying the impact of fetal growth on Body Mass Index (BMI) in young adulthood. In a nationwide cohort study, the Swedish Medical Birth Register for the years 1973-1979 was linked with the Military Service Conscription Register for 1990-1999. In 1998 a questionnaire was mailed to all male twins, included in the two registers, who were alive and still resident in Sweden. The study covers the 923 male twin pairs for which full data were available. Mixed linear models were used to estimate within-pair and between-pair differences in birthweight and their relations to BMI. A weak positive association was found among the monozygotic twins for the withinpair difference in birthweight and BMI. No significant association was found among the monozygotic for the between-pair difference in birthweight and BMI. No significant associations were found for dizygotic twins. These findings do not seem to support either the fetal programming hypothesis or the fetal insulin resistance hypothesis.