Preparation and characterization of porous hollow silica nanoparticles for drug delivery application
Preparation and characterization of porous hollow silica nanoparticles for drug delivery application
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DOI：
10.1016/s0142-9612(03)00566-0
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发表时间：
2004-02-01
期刊：
影响因子：
14
通讯作者：
Shao, L
中科院分区：
文献类型：
--
作者：
Chen, JF;Ding, HM;Shao, L
直径为60-70 nm的多孔空心二氧化硅纳米颗粒（PHSNP），使用CACO3纳米粒子作为无机模板合成了约10 nm的壁厚。 TEM和BET对PHSNP的表征表明，PHSNP是均匀的球形颗粒，具有良好的分散体，并且比表面积为867 m（2）/g。随后，将AS合成的PHSNP用作药物载体，以研究Cefradine在模拟体液中的体外释放行为。进行了紫外线光谱法和TG分析，以确定夹杂在载体中的Cefradine量。检查了夹带CEFRADINE之前和之后的PHSNP的BJH孔径分布。 PHSNP的Cefradine释放曲线遵循三阶段的模式，并表现出延迟的释放效果。 （c）2003 Elsevier Ltd.保留所有权利。
Porous hollow silica nanoparticles (PHSNP) with a diameter of 60-70 nm and wall thickness of approximately 10 nm were synthesized by using CaCO3 nano-particles as the inorganic template. The characterization of PHSNP by TEM and BET indicated that PHSNP were uniform spherical particles with good dispersion, and had a specific surface area of 867 m(2)/g. The as-synthesized PHSNP were subsequently employed as drug carrier to investigate in vitro release behavior of cefradine in simulated body fluid. UV-spectrometry and TG analyses were performed to determine the amount of cefradine entrapped in the carrier. The BJH pore size distribution of PHSNP before and after entrapping cefradine was examined. Cefradine release profile from PHSNP followed a three-stage pattern and exhibited a delayed release effect. (C) 2003 Elsevier Ltd. All rights reserved.