Sorbicillamines A-E, Nitrogen-Containing Sorbicillinoids from the Deep-Sea-Derived Fungus Penicillium sp F23-2
Sorbicillamines A-E, Nitrogen-Containing Sorbicillinoids from the Deep-Sea-Derived Fungus Penicillium sp F23-2
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DOI：
10.1021/np4006647
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发表时间：
2013-11-01
影响因子：
5.1
通讯作者：
Li, Dehai
中科院分区：
文献类型：
--
作者：
Guo, Wenqiang;Peng, Jixing;Li, Dehai
从深海真菌青霉的搅拌培养物中分离出五种新的含氮山梨西林类化合物，命名为山梨糖胺 A-E (1-5)。 F23-2，以前在静态条件下培养时产生吲哚生物碱和萜类化合物。 1至5的结构，包括绝对构型，是根据MS、NMR和圆二色性(CD)数据确定的。评估了五种新型山梨西林生物碱对 HeLa、BEL-7402、HEK-293、HCT-116 和 P388 细胞系的细胞毒性。
Five new nitrogen-containing sorbicillinoids named sorbicillamines A-E (1-5) were isolated from an agitated culture of the deep-sea-derived fungus Penicillium sp. F23-2, which has previously produced indole alkaloids and terpenoids when cultured under static conditions. The structures of 1 to 5, including absolute configurations, were determined based on MS, NMR, and circular dichroism (CD) data. The c-ytotoxicities of the five new sorbicillin alkaloids against the HeLa, BEL-7402, HEK-293, HCT-116, and P388 cell lines were evaluated.