Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltage‐dependent sodium channels in hippocampal CA1 pyramidal neurons
Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltage‐dependent sodium channels in hippocampal CA1 pyramidal neurons
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DOI：
10.1002/ptr.2902
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发表时间：
2010-01
影响因子：
7.2
通讯作者：
Yang Yao;D. Han;Tao Zhang;Zhuo Yang
中科院分区：
文献类型：
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作者：
Yang Yao;D. Han;Tao Zhang;Zhuo Yang
槲皮素是一种黄酮类化合物，存在于许多药用植物中，在中国临床上常用于治疗心血管疾病。本研究观察了槲皮素对大鼠双侧颈总动脉结扎所致慢性脑缺血的影响。槲皮素治疗（5 mg/kg，腹腔注射，连续14天）被发现可以改善缺血大鼠在Morris水迷宫中的学习和记忆能力。此外，在电生理实验中，槲皮素减弱了缺血大鼠长时程增强（LTP）的抑制。此外，在急性分离的大鼠海马CA 1锥体神经元中，槲皮素（0.3、3和30 µm）以剂量和电压依赖性方式降低电压依赖性钠电流的幅度。总之，这些数据进一步支持槲皮素的神经保护作用，并表明槲皮素对脑缺血和血管性痴呆的治疗作用可能是由于其抑制钠通道。版权所有© 2009约翰威利父子有限公司。
Quercetin is a flavonoid compound found in a number of medicinal plants that are often prescribed in Chinese clinics for the treatment of cardiovascular diseases. The present study investigated the effects of quercetin on chronic cerebral ischemia in rats produced through bilateral occlusion of the carotid arteries. Treatment of quercetin (5 mg/kg i.p. for 14 days) was found to improve the performance of learning and memory of ischemic rats in the Morris water maze. Additionally, in electrophysiological experiments, quercetin attenuated the inhibition of long‐term potentiation (LTP) in ischemic rats. Also, in acutely isolated rat hippocampal CA1 pyramidal neurons, quercetin (0.3, 3 and 30 µm) decreased the amplitude of voltage‐dependent sodium currents in a dose‐ and voltage‐dependent manner. Taken together, these data lend further support for the neuroprotective effects of quercetin and suggest that a therapeutic effect on cerebral ischemia and vascular dementia of quercetin could be due to its inhibition of sodium channels. Copyright © 2009 John Wiley & Sons, Ltd.