Nitric oxide affects microvascular permeability in the intact and inflamed vasculature
Nitric oxide affects microvascular permeability in the intact and inflamed vasculature
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DOI：
10.3109/10739689509146769
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发表时间：
1995-01-01
期刊：
影响因子：
--
通讯作者：
Kubes, Pal
中科院分区：
文献类型：
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作者：
Kubes, Pal
越来越多的证据表明，一氧化氮可以调节液体和蛋白质从血管系统中排出的运动。然而，从整个器官、单血管和内皮单层研究中获得的结果往往不一致。事实上，有很多证据表明内源性一氧化氮增加微血管通透性，同样令人信服的证据表明内源性一氧化氮降低微血管通透性。在这篇综述中，我们总结和批判性地评估迄今为止发表的数据有关的作用，一氧化氮作为一个调制器的微血管通透性在正常条件下，暴露于各种刺激。本章的最后一节讨论了一氧化氮作为炎症条件下微血管通透性调节剂的重要性。特别强调的是放在所使用的刺激，器官系统的研究，并进行测量，以调查一氧化氮对微血管通透性改变的影响。
There is a growing body of evidence that nitric oxide modulates the movement of fluid and protein out of the vasculature. However, the results obtained from whole organ, single vessel, and endothelial monolayer studies are often not consistent. In fact, there is much evidence that endogenous nitric oxide increases microvascular permeability and equally compelling evidence to suggest that endogenous nitric oxide decreases microvascular permeability. In this review we summarize and critically evaluate the data published to date regarding the role of nitric oxide as a modulator of microvascular permeability under both normal conditions and following exposure to various stimuli. The last section of the chapter discusses the importance of nitric oxide as a modulator of microvascular permeability in inflammatory conditions. Particular emphasis is placed on the stimuli used, the organ systems studied, and the measurements performed to investigate the effects of nitric oxide on microvascular permeability alterations.