Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy
Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy
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DOI：
10.1016/j.ejca.2008.12.026
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发表时间：
2009-05-01
影响因子：
8.4
通讯作者：
Eremin, Oleg
中科院分区：
文献类型：
--
作者：
Chuthapisith, Suebwong;Bean, Beverley E.;Eremin, Oleg
新辅助化疗用于患有大或局部晚期乳腺癌的女性。然而，高达70%的接受新辅助化疗的女性未能在其原发肿瘤中实现完全的病理学反应（长期生存的替代标志物）。在我们的体外实验中，先前确定与化疗耐药性有关的五种蛋白质，在40名患有大型或局部晚期乳腺癌的妇女的治疗前芯针活检中进行了组织化学鉴定。免疫组织化学染色与五种蛋白质显示没有单一的蛋白质是一个预测化疗的反应。然而，膜联蛋白-A2阳性但膜联蛋白-A1阴性的治疗前乳腺癌标本与不良病理学反应相关（p = 0.04，Fisher精确检验）。膜联蛋白赋予化学抗性的机制尚未确定，但可能是由于抑制细胞凋亡。膜联蛋白-A1已被证明可增强细胞凋亡，而膜联蛋白-A2则相反，可抑制细胞凋亡。(c)2008爱思唯尔有限公司版权所有。
Neoadjuvant chemotherapy is used in women who have large or locally advanced breast cancers. However, up to 70% of women who receive neoadjuvant chemotherapy fail to achieve a complete pathological response in their primary tumour (a surrogate marker of long-term survival). Five proteins, previously identified to be linked with chemoresistance in our in vitro experiments, were identified histochemically in pre-treatment core needle biopsies from 40 women with large or locally advanced breast cancers. Immunohistochemical staining with the five proteins showed no single protein to be a predictor of response to chemotherapy. However, pre-treatment breast cancer specimens that were annexin-A2 positive but annexin-A1 negative correlated with a poor pathological response (p = 0.04, Fisher's exact test). The mechanisms by which annexins confer chemoresistance have not been identified, but may be due to inhibition of apoptosis. Annexin-A1 has been shown to enhance apoptosis, whilst annexin-A2, by contrast, inhibits apoptosis. (c) 2008 Elsevier Ltd. All rights reserved.