Place cells and place recognition maintained by direct entorhinal-hippocampal circuitry
Place cells and place recognition maintained by direct entorhinal-hippocampal circuitry
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DOI：
10.1126/science.1071089
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发表时间：
2002-06-21
期刊：
影响因子：
56.9
通讯作者：
Moser, EI
中科院分区：
文献类型：
--
作者：
Brun, VH;Otnæss, MK;Moser, EI
海马CA 1区的位置细胞可能从CA 3区的海马内联想网络或直接从内嗅皮层接收位置信息。为了确定直接内嗅连接是否支持空间环和空间记忆，我们删除了CA 3到CA 1区域的所有输入，从而隔离了CA 1区域。孤立CA 1区锥体细胞产生尖锐而稳定的位置场。大鼠与孤立的CA 1区表现出正常收购的一个关联的海马依赖的空间识别任务。空间记忆受损。这些结果表明，海马包含两个功能上可分离的记忆回路：直接内鼻-CA 1系统足以用于基于回忆的识别记忆，但回忆依赖于完整的CA 3-CA 1连接。
Place cells in hippocampal area CA1 may receive positional information from the intrahippocampal associative network in area CA3 or directly from the entorhinal cortex. To determine whether direct entorhinal connections support spatial ring and spatial memory, we removed all input from areas CA3 to CA1, thus isolating the CA1 area. Pyramidal cells in the isolated CA1 area developed sharp and stable place fields. Rats with an isolated CA1 area showed normal acquisition of an associative hippocampal-dependent spatial recognition task. Spatial recall was impaired. These results suggest that the hippocampus contains two functionally separable memory circuits: The direct entorhinal-CA1 system is sufficient for recollection-based recognition memory, but recall depends on intact CA3-CA1 connectivity.