Reduced cerebellar inhibition in schizophrenia: A preliminary study
Reduced cerebellar inhibition in schizophrenia: A preliminary study
复制标题
DOI：
10.1176/appi.ajp.162.6.1203
复制
发表时间：
2005-06-01
影响因子：
17.7
通讯作者：
Chen, R
中科院分区：
文献类型：
--
作者：
Daskalakis, ZJ;Christensen, BK;Chen, R
Objective: Postmortem and structural imaging studies suggest that patients with schizophrenia have disrupted cerebellar activity. It has been speculated that these abnormalities mediate disorganized thought processes and psychosis. The authors' goal was to use transcranial magnetic stimulation to measure cerebellar inhibition, a proxy of cerebellar activity, as the principal output of the cerebellum is inhibitory.Method: Cerebellar inhibition was accomplished by delivering a magnetic cerebellar conditioning stimulus 5-15 msec before a magnetic test stimulus to the motor cortex. The cerebellar conditioning stimulus inhibits the size of the motor evoked potential produced by the test stimulus by approximately 50%. Ten patients with schizophrenia and 10 healthy comparison subjects completed the cerebellar inhibition protocol.Results: Patients with schizophrenia demonstrated significant deficits in cerebellar inhibition compared with healthy subjects.Conclusions: The authors conclude that deficits in cerebellar inhibitory activity in schizophrenia may be the result of an abnormality in the cerebellum or disrupted cerebellar-thalamic-cortical connectivity.
