Cell adhesion and regulatory molecules involved in tumor formation, hemostasis, and wound healing.
Cell adhesion and regulatory molecules involved in tumor formation, hemostasis, and wound healing.
复制标题
细胞粘附和调节分子参与肿瘤形成、止血和伤口愈合。
DOI：
10.1002/hed.2880170212
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
VanWaes,C
中科院分区：
文献类型：
--
作者：
VanWaes,C
背景：细胞粘附和迁移的动态变化是细胞的基本特性，在止血、血管形成和创伤修复中起重要作用。细胞粘附和迁移的变化是非常重要的，在肿瘤的形成，侵袭和转移的肿瘤。方法。使用免疫定位和免疫纯化技术，参与细胞粘附的整合素分子的表达，其特征在于在肿瘤的发展和伤口愈合。为了更好地理解整合素在发病机制中的作用，研究了细胞因子调节整合素表达的能力以及抗体和肽抑制剂抑制整合素功能的能力。结果：整合素α6β4、α2β1和α3β1的基底膜上表达增加伴随着头颈部鳞状细胞肿瘤的发展。整合素α 11 β3是整合素受体，其在止血和肿瘤转移形成中的血小板聚集中是重要的。整合素αvβ3在血管生成中的表达增加是对生长因子和肿瘤血管生成因子的应答。细胞因子TGF-β和花生四烯酸代谢产物12（S）-HETE是调节整合素的重要信号，并影响这些过程中的细胞聚集和迁移。这些受体的配体和抑制剂已被确定，这将是有用的，在确定其作用在肿瘤的发展和progression.Conclusions.最近的进展，了解整合素细胞粘附分子的功能可能很快增加新的诊断方法和治疗的头部和颈部肿瘤，微血管，整形，重建外科医生的医疗设备。正在探索针对控制整联蛋白细胞粘附分子表达和功能的疗法，以改善瘢痕形成、骨合成、抑制血管闭塞以及抑制肿瘤侵袭和转移。© 1995容斯威利父子公司
Background.Dynamic changes in cell adhesion and migration are fundamental properties of the cells that are important in hemostasis, vascularization, and wound repair. Changes in cell adhesion and migration are very important in the formation of tumors, and invasion and metastasis by neoplasms.Methods.Using immunolocalization and immunopurification techniques, expression of integrin molecules involved in cell adhesion has been characterized during tumor development and wound healing. The ability of cytokines to regulate expression and antibody and peptide inhibitors to inhibit function of integrins has been explored to better understand the role of integrins in pathogenesis.Results.Increased suprabasilar expression of the integrins α6β4, α2β1, and α3β1 accompanies development of squamous cell neoplasms of the head and neck. Integrin αllβ3 is an integrin receptor which is important in platelet aggregation in hemostasis and formation of tumor metastases. Increased expression of integrin αvβ3 has been identified in angiogenesis in response to growth factors and tumor angiogenic factors. Cytokine TGF‐β and arachadonic acid metabolite 12(S)‐HETE are important signals in regulation of integrins and affect cell aggregation and migration in these processes. Ligands and inhibitors for some of these receptors have been identified which will be useful in determining their role during tumor development and progression.Conclusions.Recent advances in understanding the functions of the integrin cell adhesion molecules may soon add new diagnostic methods and therapies to the armamentarium of the head and neck oncologic, microvascular, plastic, and reconstructive surgeon. Therapies directed at controlling integrin cell‐adhesion molecule expression and function are being explored to improve scar formation, bone synthesis, inhibition of vascular occlusion, and inhibition of tumor invasion and metastasis. © 1995 Jons Wiley & Sons, Inc.