The effects of exercise on dynamic sleep morphology in healthy controls and patients with chronic fatigue syndrome.
The effects of exercise on dynamic sleep morphology in healthy controls and patients with chronic fatigue syndrome.
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DOI：
10.1002/phy2.152
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发表时间：
2013-11
影响因子：
2.5
通讯作者：
Natelson, Benjamin H
中科院分区：
文献类型：
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作者：
Kishi, Akifumi;Togo, Fumiharu;Cook, Dane B;Klapholz, Marc;Yamamoto, Yoshiharu;Rapoport, David M;Natelson, Benjamin H
运动对睡眠动态方面的影响尚未研究。我们假设运动改变动态睡眠形态不同的健康对照组相对于慢性疲劳综合征（CFS）患者。16名对照组（38 ± 9岁）和17名CFS患者（41 ± 8岁）在基线夜间和最大运动试验后的夜间进行了多导睡眠图检查。我们计算了睡眠阶段之间的转换概率和转换率（分别作为相对转换频率和时间转换频率的度量）以及每个睡眠阶段和整个睡眠的累积持续时间分布（作为连续性的度量）。运动后，对照组显示从N1到N2的转换概率显著高于基线，从N1到清醒的转换率较低; CFS显示从N2到N3的转换概率显著高于基线，从N2到N1的转换率较低。这些发现表明运动后睡眠质量有所改善。运动后，对照组的睡眠连续性有所改善，而CFS组的N1睡眠连续性较低，而快速眼动（REM）睡眠连续性较高。然而，CFS有一个显着更大的概率和速度从REM到唤醒的过渡比对照组。从REM到清醒的转变概率与CFS中主观疲劳、疼痛和夜间嗜睡的增加显著相关-这表明这些转变可能与患者抱怨睡眠不清醒有关。因此，对于对照组和CFS，运动促进了向深度睡眠阶段的过渡，抑制了向浅睡眠阶段的过渡，但CFS也报告了疲劳增加，并继续发生REM睡眠中断。这种分离表明CFS潜在病理学的可能机制途径。
Effects of exercise on dynamic aspects of sleep have not been studied. We hypothesized exercise altered dynamic sleep morphology differently for healthy controls relative to chronic fatigue syndrome (CFS) patients. Sixteen controls (38 ± 9 years) and 17 CFS patients (41 ± 8 years) underwent polysomnography on baseline nights and nights after maximal exercise testing. We calculated transition probabilities and rates (as a measure of relative and temporal transition frequency, respectively) between sleep stages and cumulative duration distributions (as a measure of continuity) of each sleep stage and sleep as a whole. After exercise, controls showed a significantly greater probability of transition from N1 to N2 and a lower rate of transition from N1 to wake than at baseline; CFS showed a significantly greater probability of transition from N2 to N3 and a lower rate of transition from N2 to N1. These findings suggest improved quality of sleep after exercise. After exercise, controls had improved sleep continuity, whereas CFS had less continuous N1 and more continuous rapid eye movement (REM) sleep. However, CFS had a significantly greater probability and rate of transition from REM to wake than controls. Probability of transition from REM to wake correlated significantly with increases in subjective fatigue, pain, and sleepiness overnight in CFS – suggesting these transitions may relate to patient complaints of unrefreshing sleep. Thus, exercise promoted transitions to deeper sleep stages and inhibited transitions to lighter sleep stages for controls and CFS, but CFS also reported increased fatigue and continued to have REM sleep disruption. This dissociation suggests possible mechanistic pathways for the underlying pathology of CFS.