Improved targetry and production of iodine-124 for PET studies
Improved targetry and production of iodine-124 for PET studies
复制标题
DOI：
10.1524/ract.92.12.951.55103
复制
发表时间：
2004-01-01
影响因子：
1.8
通讯作者：
Luthra, SK
中科院分区：
文献类型：
--
作者：
Glaser, M;Mackay, DB;Luthra, SK
碘-124（T-1/2 = 4.18d）是正电子发射断层扫描（PET）临床前研究的重要核素。我们描述了一种改进的方法来生产和提取1241从固体[Te-124] TeO 2目标有效地使用干馏技术。我们的工艺基于远程热室处理，并进行了优化，以实现优于90%的效率，平均厚靶产率为9.0 +/- 1.0 MBq/muAh（n=47，衰减校正）。该技术是安全的，并减少了操作者的剂量。
Iodine-124 (T-1/2 = 4.18d) is an important radionuclide for preclinical research in positron emission tomography (PET). We describe an improved method to produce and extract 1241 from a solid [Te-124]TeO2 target efficiently using the dry distillation technique. Our process is based on remote hot cell handling and was optimised to achieve efficiencies better than 90% with an average thick target yield of 9.0 +/- 1.0 MBq/muAh (n=47, corrected for decay). The technology is safe and reduces the dose to the operator.