Structural Reorganization of the Vaginal Mucosa in Stress Urinary Incontinence under Conditions of Er:YAG Laser Treatment
Structural Reorganization of the Vaginal Mucosa in Stress Urinary Incontinence under Conditions of Er:YAG Laser Treatment
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DOI：
10.1007/s10517-017-3650-0
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发表时间：
2017-02-01
影响因子：
0.7
通讯作者：
Neimark, A. I.
中科院分区：
文献类型：
--
作者：
Lapii, G. A.;Yakovleva, A. Yu.;Neimark, A. I.
研究压力性尿失禁阴道粘膜的结构特点及IncontiLase技术对压力性尿失禁的矫正作用。暴露前的阴道活检标本研究显示复层鳞状上皮退行性和萎缩性变化，细胞间基质纤维结构解体，微循环障碍。Er：YAG激光照射后的研究显示了新胶原生成和弹性纤维生成的迹象，新血管生成的病灶，上皮变性和萎缩的减少，以及成纤维细胞数量的增加。形态计量学显示，毛细血管体积密度和上皮层厚度分别增加了61.1%和64.5%。IncontiLase技术在压力性尿失禁中的使用导致阴道粘膜的结构重组，改善其形态和功能，并缓解失禁症状。
Structural characteristics of the vaginal mucosa in stress incontinence and its correction by IncontiLase technology were studied. Studies of vaginal biopsy specimens before the exposure showed degenerative and atrophic changes in the stratified squamous epithelium, disorganization of fibrillar structures of the intercellular matrix, and microcirculatory disorders. Studies after Er:YAG laser exposure showed signs of neocollagenogenesis and elastogenesis, foci of neoangiogenesis, reduction of epithelial degeneration and atrophy, and an increase of the fibroblast population. Morphometry showed that the volume density of blood capillaries and the thickness of the epithelial layer increased by 61.1 and 64.5%, respectively. The use of IncontiLase technology in stress incontinence led to structural reorganization of the vaginal mucosa, improving its morphology and function and alleviating the symptoms of incontinence.