A new locus (Mtv-4) for endogenous mammary tumor virus expression and early mammary tumor development in the SHN mouse strain.
A new locus (Mtv-4) for endogenous mammary tumor virus expression and early mammary tumor development in the SHN mouse strain.
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SHN 小鼠品系中用于内源性乳腺肿瘤病毒表达和早期乳腺肿瘤发育的新基因座 (Mtv-4)。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
R. Michalides
中科院分区：
文献类型：
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作者：
S. Imai;Y. Tsubura;J. Hilgers;R. Michalides
SHN 小鼠品系具有高乳腺癌发病率，是由 H. Nagasawa 博士及其同事（日本东京明治大学）通过近交和从瑞士种小鼠中选育而培育出来的，其携带内源性乳腺肿瘤病毒 (MTV)，导致生命早期乳腺肿瘤的高发率。该基因座被称为“Mtv-4”，其诱导乳腺癌的能力仅与GR小鼠品系的Mtv-2相当。与32P标记的MTV互补DNA的分子杂交表明，SHN菌株中不存在GR菌株的特征性Mtv-2条带。
The SHN mouse strain, which has a high incidence of mammary cancer, developed by inbreeding and selection from Swiss stock mice by Dr. H. Nagasawa and co-workers (Meiji University, Tokyo, Japan), harbored an endogenous mammary tumor virus (MTV) responsible for a high frequency of mammary tumors early in life. The locus was called "Mtv-4" and was only comparable with Mtv-2 of the GR mouse strain in its inducing capacity of mammary cancer. Molecular hybridization with 32P-labeled MTV complementary DNA showed that the characteristic Mtv-2 bands of the GR strain were absent in the SHN strain.