Severe acute respiratory syndrome among children
Severe acute respiratory syndrome among children
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DOI：
10.1542/peds.113.6.e535
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发表时间：
2004-06-01
期刊：
影响因子：
8
通讯作者：
Chiu, MC
中科院分区：
文献类型：
--
作者：
Leung, CW;Kwan, YW;Chiu, MC
目标。研究严重急性呼吸综合征(SARS)患儿的流行病学、临床、实验室和放射学特征、预后指标和中短期预后，并验证根据SARS相关冠状病毒(SARS-CoV)血清转换计算的临床病例定义的表现特征。12岁的儿童与氧气需求有关。喉咙痛、发病时中性粒细胞计数升高和中性粒细胞峰值是预测病情严重的独立因素。临床病例定义具有良好的敏感性、特异性、阳性预测值和阴性预测值(分别为97.8%、92.7%、88%和98.7%)。儿童容易感染SARS冠状病毒。青少年在疾病进展方面与成年人相似，可能会患上严重疾病。短期到中期的结果是好的。喉咙痛和最初的和高峰的中性粒细胞增多似乎是严重疾病的预测指标。我们的临床病例定义在疫情中表现良好。
Objective. To study the epidemiologic, clinical, laboratory, and radiologic features, prognostic indicators, and short-term to medium-term outcomes for children with severe acute respiratory syndrome (SARS) and to validate the performance characteristics of a clinical case definition, calculated with respect to SARS-associated coronavirus (SARS-CoV) seroconversion.Methods. Children 12 years was associated with oxygen requirements. Sore throat, high neutrophil count at presentation, and peak neutrophilia were independent factors predicting severe illness. The clinical case definition demonstrated good sensitivity, specificity, and positive and negative predictive values (97.8%, 92.7%, 88%, and 98.7%, respectively) for diagnostic accuracy.Conclusions. Children are susceptible to SARS-CoV infection. Teenagers resemble adults with respect to disease progression and may develop severe illness. The short-term to medium-term outcomes are good. Sore throat and initial and peak neutrophilia seem to be predictors of severe illness. Our clinical case definition performed well in the epidemic.