Limited allelic diversity of Plasmodium falciparum merozoite surface protein 1 gene from populations in the Solomon Islands
Limited allelic diversity of Plasmodium falciparum merozoite surface protein 1 gene from populations in the Solomon Islands
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DOI：
10.4269/ajtmh.2006.74.31
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发表时间：
2006-01-01
影响因子：
3.3
通讯作者：
Tanabe, K
中科院分区：
文献类型：
--
作者：
Sakihama, N;Ohmae, H;Tanabe, K
恶性疟原虫裂殖子表面蛋白1（msp 1）基因减数分裂重组产生等位基因多样性。在这项研究中，我们监测了疟疾传播率高的所罗门群岛的瓜达尔卡纳尔岛的msp 1基因重组多样性。我们确定了5'重组类型，3'序列类型和msp 1单倍型（5'重组类型和3'序列类型的独特关联），并将其与泰国和瓦努阿图低传播地区的单倍型进行了比较。瓜达尔卡纳尔岛的人均5'重组型数（多重性）低于泰国。瓜达尔卡纳尔岛人群有6-8个msp 1单倍型;数量与瓦努阿图相当，但远低于泰国。171个spl单倍型的分布存在明显的地理差异。在msp 1的连锁不平衡更强，在瓜达尔卡纳尔岛比在泰国，这表明有限的重组事件在所罗门群岛。我们认为，在MSP 1的重组事件的频率不仅由传输强度，但由MSP 1等位基因的数量普遍和多重感染。
Meiotic recombination generates allelic diversity in the Plasmodium falciparum merozoite surface protein 1 (msp1) gene. In this study, we monitored recombination-based diversity of msp1 in Guadalcanal, the Solomon Islands, where malaria transmission is high. We identified 5' recombinant types, 3' sequence types, and msp1 haplotypes (unique associations of 5' recombinant types and 3' sequence types), and compared them with those from areas of low transmission in Thailand and Vanuatu. The mean number of 5' recombinant types per person (multiplicity) was lower in Guadalcanal than in Thailand. Guadalcanal populations had 6-8 msp1 haplotypes; the numbers are comparable to Vanuatu but much lower than in Thailand. There were marked geographic differences in distribution Of 171spl haplotypes. Linkage disequilibrium in msp1 was stronger in Guadalcanal than in Thailand, suggesting limited recombination events in the Solomon Islands. We suggest that the frequency of recombination events In msp1 is determined not only by transmission intensity but by the number of msp1 alleles prevalent and multiplicity of infections.