Mapped! A machinery of degranulation in mast cells. Focus on "Serum- and glucocorticoid-inducible kinase SGK1 regulates reorganization of actin cytoskeleton in mast cells upon degranulation".
Mapped! A machinery of degranulation in mast cells. Focus on "Serum- and glucocorticoid-inducible kinase SGK1 regulates reorganization of actin cytoskeleton in mast cells upon degranulation".
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DOI：
10.1152/ajpcell.00330.2012
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Hua,SusanZ
中科院分区：
文献类型：
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作者：
Hua,SusanZ
肥大细胞（MC）是免疫系统的一个组成部分，介导炎症反应和过敏性免疫反应。MC参与多种过敏性疾病，如过敏性反应、过敏性鼻炎和哮喘（2，3）。MC可通过IgE与MC膜上的高亲和力IgE受体（FcεRI）的连接11以及其他物理刺激12或化学刺激激活。在激活时，MC从其13个细胞质颗粒释放多种免疫介质，这是一种称为脱粒的细胞过程。脱粒机制14涉及细胞内Ca2+和肌动蛋白细胞骨架解体的增加，这使得分泌囊泡能够移动到质膜。因此，调节Ca2+依赖的肌动蛋白16细胞骨架动力学是MC最终脱粒的关键步骤。以前，已经证明血清和糖皮质激素诱导的激酶（SGK1）是MC中颗粒的18Ca2+进入和胞吐的有力调节剂（7）。然而，这幅图中缺少的一个环节是SGK1在肌动蛋白解聚中的作用，肌动蛋白解聚导致脱粒。Shumilina和他的同事们的工作已经更完整地描绘了这幅图。21
8 Mast cells (MCs) are a component of the immune system, that mediates inflammatory 9 responses and allergic immune reactions. MCs are involved in a variety of allergic diseases such 10 as anaphylaxis, allergic rhinitis and asthma (2, 3). The MCs can be activated via the attachment 11 of IgE to high-affinity IgE receptors (FcεRI) on the MC membrane, as well as by other physical 12 or chemical stimuli. Upon activation, MCs release a variety of immune mediators from their 13 cytoplasmic granules, a cellular process called degranulation. The machinery of degranulation 14 involves an increase in intracellular Ca2+ and actin cytoskeleton disassembly that enables the 15 secretory vesicles to move to the plasma membrane. Thus, regulation of Ca2+-dependent actin 16 cytoskeleton dynamics is a crucial step in the eventual degranulation of MCs. Previously, it has 17 been shown that serum-and glucocorticoid-inducible kinase (SGK1) is a powerful regulator of 18 Ca2+ entry and exocytosis of granules in MCs (7). However, a missing link in this picture has 19 been the role of SGK1 in actin depolymerization that leads to degranulation. Now this picture 20 has been more completely mapped by the work of Shumilina and co-workers (5). 21