Stereoselective glycosylation with conformation-constrained 2-Nitroglycals as donors and bifunctional thiourea as catalyst
Stereoselective glycosylation with conformation-constrained 2-Nitroglycals as donors and bifunctional thiourea as catalyst
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DOI：
10.1080/07328303.2021.2023560
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发表时间：
2021-11
影响因子：
1
通讯作者：
Yongyong Wan;Xiaopei Wu;Yunxia Xue;Xi-E Lin;Liming Wang;Jiansong Sun;Qingju Zhang
中科院分区：
文献类型：
--
作者：
Yongyong Wan;Xiaopei Wu;Yunxia Xue;Xi-E Lin;Liming Wang;Jiansong Sun;Qingju Zhang
本文报道了一种利用构象受限的2-硝基供体和双功能硫脲催化剂高效、立体选择性地构筑1，2-顺-2-氨基-2-脱氧-糖苷键的新方法。该方法反应条件温和，立体选择性好至优，底物范围宽，效率好至优。图形摘要
Abstract Herein, we report a novel method for highly efficient and stereoselective construction 1,2-cis-2-amino-2-deoxy-glycosidic linkages using conformation-constrained 2-nitroglycal donors and bifunctional thiourea catalyst. The method enjoys mild reaction conditions, good to excellent stereoselectivity, broad substrate scope, and good to excellent efficiency. Graphical Abstract