Potential impact of rapid diagnostic tests on improving antimicrobial use
Potential impact of rapid diagnostic tests on improving antimicrobial use
复制标题
快速诊断测试对改善抗菌药物使用的潜在影响
DOI：
10.1111/j.1749-6632.2010.05827.x
复制
发表时间：
2010
影响因子：
5.2
通讯作者：
F. Tenover
中科院分区：
文献类型：
--
作者：
F. Tenover
抗菌药物管理计划促进个人患者最佳的抗菌药使用，并减少卫生保健中不适当的抗菌剂使用，以限制导致多重耐药微生物发展和传播的选择压力。这些努力假定微生物实验室提供的作为临床决策基础的抗菌素敏感性测试(AST)数据是准确的，并及时提供。然而，常规的AST数据通常在从患者身上收集用于培养的临床标本后两到三天才能获得。核酸扩增方法可以直接从临床标本中提供抗菌素耐药微生物的存在数据，通常不到1小时。引起败血症、呼吸道感染和性传播疾病的生物体都可以快速检测到。几种商业化的分子诊断分析方法已经在世界各地的微生物学实验室中使用；然而，医生对快速方法的接受往往很慢。在不到一小时的时间内，临床样本中出现耐药细菌的数据应该会提高抗菌药物管理计划的有效性。
Antimicrobial stewardship programs promote optimal antimicrobial use in the individual patient and reductions in inappropriate antimicrobial use in health care to limit the selective pressures that contribute to the development and spread of multidrug‐resistant organisms. These efforts presume that the antimicrobial susceptibility testing (AST) data provided by the microbiology laboratory, which serve as the basis for clinical decision making, are accurate and delivered in a timely fashion. However, routine AST data are often not available until two to three days after the clinical specimen for culture has been collected from the patient. Nucleic acid amplification methods can provide data on the presence of antimicrobial‐resistant microorganisms directly from clinical specimens often in less than 1 hour. Organisms causing sepsis, respiratory tract infections, and sexually transmitted diseases are all amenable to rapid detection. Several commercial molecular diagnostic assays are already in use in microbiology laboratories worldwide; however, physician acceptance of the rapid methods is often slow. Data on the presence of resistant bacteria in a clinical sample in less than one hour should improve the effectiveness of antimicrobial stewardship programs.
影响因子：
158.5
作者：
RELMAN, DA;LOUTIT, JS;TOMPKINS, LS
通讯作者：
TOMPKINS, LS