Equol status modifies the association of soy intake and mammographic density in a sample of postmenopausal women
Equol status modifies the association of soy intake and mammographic density in a sample of postmenopausal women
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DOI：
10.1158/1055-9965.epi-07-0193
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发表时间：
2008-01-01
影响因子：
3.8
通讯作者：
Muti, Paola C.
中科院分区：
文献类型：
--
作者：
Fuhrman, Barbara J.;Teter, Barbara E.;Muti, Paola C.
只有30%到50%的人在食用大豆后产生大豆素代谢物雌马酚。我们对纽约州布法罗附近一家放射诊所招募的绝经后妇女样本进行了一项关于雌马酮状况、大豆食品摄入和乳房x线摄影密度之间关系的横断面研究。参与者年龄在48至82岁之间，没有癌症或乳房缩小/隆胸史，近期没有使用抗生素或激素。百分比密度是通过计算机辅助分析颅-趾部影像的数字化图像来测量的。使用大豆挑战方案评估雌马酚状态，并通过问卷调查评估通常的大豆摄入量。使用一般线性模型来评估雌马酚状态和大豆摄入量对多变量调整百分比密度的独立和联合影响（协变量包括年龄、体重指数、胎次、初产年龄和曾经使用过联合激素治疗）。在325名入组患者中，232名（71%）参与者完成了研究评估并纳入本分析。平均百分比密度为34%（±18%）。75名（30%）参与者是雌马酚的生产者。43名（19%）参与者报告说，他们每周经常吃100多份大豆食品或补充剂。雌马酚水平和大豆摄入量与百分比密度之间没有显著的独立相关性，但它们之间存在显著的交互作用（P < 0.01）。在雌马酚生产者中，每周摄入大豆的人的百分比密度较低（每周摄入大豆的人为30.7%，而其他人为38.9%,P = 0.08）；在非生产者中，每周大豆摄入量与较高的百分比密度相关（每周大豆消费者为37.5%，而其他人为30.7%;P = 0.03）。结果表明，雌马酚产生者和非产生者可能会经历不同的饮食大豆对乳房组织的影响。
Only 30% to 50% of people produce the daidzeinmetabolite equol after eating soy. We conducted a cross-sectional study of the associations between equol status, intake of soy foods, and mammographic density in a sample of postmenopausal women recruited at a radiology clinic near Buffalo, New York. Participants were 48 to 82 years old, had no history of cancer or breast reduction/augmentation, and no recent use of antibiotics or hormones. Percent density was measured by computer-assisted analysis of digitized images of craniocaudal films. Equol status was assessed using a soy-challenge protocol and usual soy intake by questionnaire. General linear models were used to assess independent and joint effects of equol status and intake of soy on multivariate adjusted percent density (covariates included age, body mass index, parity, age at first birth, and ever use of combined hormone therapy). Of 325 enrolled, 232 (71%) participants completed study assessments and are included in the present analysis. Mean percent density was 34% (+/- 18%). Seventy-five (30%) participants were producers of equol. Forty-three (19%) participants reported regularly eating > 1 soy food or supplement/wk. There were no significant independent associations of equol status or soy intake with percent density, but the interaction between these factors was significant (P < 0.01). Among equol producers, those with weekly soy intake had lower percent density (30.7% in weekly consumers of soy versus 38.9% in others; P = 0.08); among nonproducers, weekly soy intake was associated with higher percent density (37.5% in weekly soy consumers versus 30.7% in others; P = 0.03). Results suggest that equol producers and nonproducers may experience different effects of dietary soy on breast tissue.