UV Light-Mediated Difunctionalization of Alkenes through Aroyl Radical Addition/1,4-/1,2-Aryl Shift Cascade Reactions
UV Light-Mediated Difunctionalization of Alkenes through Aroyl Radical Addition/1,4-/1,2-Aryl Shift Cascade Reactions
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通过芳酰基自由基加成/1,4-/1,2-芳基转移级联反应进行紫外光介导的烯烃双官能化
DOI：
10.1021/acs.orglett.5b00144
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发表时间：
2015
期刊：
影响因子：
5.2
通讯作者：
Xia Wujiong
中科院分区：
文献类型：
--
作者：
Zheng Lewei;Huang Hongli;Yang Chao;Xia Wujiong
报道了紫外光通过芳酰基自由基加成/1，4-/1，2-芳基转移对烯烃进行的双官能化反应。丙烯酰胺类化合物通过光解反应生成芳酰基，然后环合生成氧吲哚，而肉桂酰胺类化合物则发生了独特的1，4-芳基转移反应。此外，还通过芳基自由基加成和1，2-芳基转移级联反应实现了丙烯-2-烯-1-醇的双官能化。
UV light-mediated difunctionalization of alkenes through an aroyl radical addition/1,4-/1,2-aryl shift has been described. The resulted aroyl radical from a photocleavage reaction added to acrylamide compounds followed by cyclization led to the formation of oxindoles, whereas the addition to cinnamic amides aroused a unique 1,4-aryl shift reaction. Furthermore, the difunctionalization of alkenes of prop-2-en-1-ols was also achieved through aroyl radical addition and a sequential 1,2-aryl shift cascade reaction.