Hypothalamic-pituitary-adrenal reactivity in boys with attention deficit hyperactivity disorder
Hypothalamic-pituitary-adrenal reactivity in boys with attention deficit hyperactivity disorder
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DOI：
10.3349/ymj.2003.44.4.608
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发表时间：
2003-08-30
影响因子：
2.4
通讯作者：
Noh, KS
中科院分区：
文献类型：
--
作者：
Hong, HJ;Shin, DW;Noh, KS
假设“是否与注意缺陷/多动障碍（ADHD），谁表现出下丘脑-垂体-肾上腺（HPA）轴的反应性不足的压力，将作出更多的委托错误的注意任务”，进行了检查。43名患有多动症的男孩，他们在江北三星医院的精神科门诊就诊，是这项研究的对象。测试前和测试后的早晨唾液样本均收集自患者，采用韩国教育发展研究所-韦氏儿童智力量表（KEDI-WISC）和注意力变量测试（T.O.V.A.）执行。比较唾液皮质醇水平降低或升高的患者的T. O. V. A标准评分。测试后唾液皮质醇水平的降低或升高分别见于28例和15例患者。测试后皮质醇水平降低的患者比皮质醇水平升高的患者更容易犯委托错误。测试后皮质醇水平降低的患者在测试的第一季度有更多的遗漏错误，在测试的后半部分有更多的委托错误。压力后唾液皮质醇水平下降的受试者在注意力测试中出现更多的委托错误。这提示，ADHD患者HPA轴对应激反应的迟钝与冲动性有关。
The hypothesis 'whether subjects with attention-deficit/hyperactivity disorder (ADHD), who showed under-reactivity of the hypothalamic-pituitary-adrenal (HPA) axis to stress, would make more commission errors in attention tasks', was examined. Forty-three boys, with ADHD, who visited the psychiatric outpatient clinic, at Kangbuk Samsung Hospital, were the subjects of this study. Both pre- and post-test morning saliva samples were collected from the patients at the Korean Educational Development Institute-Wechsler Intelligence Scale for Children (KEDI-WISC), and Tests of Variables of Attention (T.O.V.A.) performed. The Standard scores of the T.O.V.A were compared between the patients with decreases, or increases, in the salivary cortisol levels after the test. Decreases, or increases in the salivary cortisol levels after the test were shown in 28 and 15 patients, respectively. The patients with decreased cortisol levels after the test tended to make more commission errors in compared with those with increased cortisol levels. The patients with the decreased cortisol levels after test had more omission errors in the first quarter of the test, and more commission errors in the second half of the test compared to those with the increased cotisol levels. Subjects who show decreased salivary cortisol levels after stress make more commission errors in attention tests. This suggests that the blunted HPA axis response to stress is related to the impulsivity in patients with ADHD.