Ultrasound‐enhanced localized chemotherapy of drug‐sensitive and multidrug resistant tumors
Ultrasound‐enhanced localized chemotherapy of drug‐sensitive and multidrug resistant tumors
复制标题
药物敏感和多重耐药肿瘤的超声增强局部化疗
DOI：
10.1063/1.2205521
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
D. Christensen
中科院分区：
文献类型：
--
作者：
N. Rapoport;Zhong;P. Kamaev;D. Christensen
一种新的肿瘤靶向化疗模式是基于药物包封在聚合物纳米颗粒中，然后通过聚焦超声触发在肿瘤部位局部释放。在nu/nu小鼠卵巢癌肿瘤中，测量了局部应用1 MHz和3 MHz非聚焦超声对阿霉素（DOX）生物分布和肿瘤生长速率的影响。从系统和细胞水平研究了超声的生物效应。胶束给药与肿瘤照射相结合可显著降低A2780卵巢癌肿瘤的生长速率。超声处理过程中的肿瘤内温度测量表明，超声效应不是热效应。生物分布研究表明，超声并没有增强胶束外渗。超声增强化疗的主要机制包括：（i）载药胶束被动靶向肿瘤组织;（ii）超声触发肿瘤体积中胶束的局部药物释放;（iii）超声触发肿瘤体积中胶束的局部药物释放。
A new modality of targeted tumor chemotherapy is based on the drug encapsulation in polymeric nanoparticles followed by a localized release at the tumor site triggered by focused ultrasound. Effect of 1 MHz and 3 MHz unfocused ultrasound applied locally to the tumor on the Doxorubicin (DOX) biodistribution and tumor growth rates was measured for ovarian carcinoma tumors in nu/nu mice. The bioeffects of ultrasound were investigated on the systemic and cellular levels. Growth rates of A2780 ovarian carcinoma tumors were substantially reduced by combining micellar drug delivery with tumor irradiation. Ultrasound effect was not thermal as manifested by intratumoral temperature measurements during sonication. Biodistribution studies showed that ultrasound did not enhance micelle extravasation. Main mechanisms of the ultrasound‐enhanced chemotherapy included (i) passive targeting of drug‐loaded micelles to the tumor interstitium; (ii) ultrasound‐triggered localized drug release from micelles in the tumor volume...