CLINICAL-TRIALS OF BIVALENT INFLUENZA-A-NEW-JERSEY-76-A-VICTORIA-75 VACCINES IN ELDERLY
CLINICAL-TRIALS OF BIVALENT INFLUENZA-A-NEW-JERSEY-76-A-VICTORIA-75 VACCINES IN ELDERLY
复制标题
DOI：
10.1093/infdis/136.supplement_3.s518
复制
发表时间：
1977-01-01
影响因子：
6.4
通讯作者：
KNIGHT, V
中科院分区：
文献类型：
--
作者：
CATE, TR;KASEL, JA;KNIGHT, V
在老年人中进行的这项含有200或400个鸡细胞凝集单位的A/New Jersey/76和A/Victoria/75抗原的灭活流感病毒疫苗的安慰剂对照评估显示，7.8%的受试者出现轻度全身反应，4.9%的受试者出现中度反应。这些反应在接种全病毒疫苗后比亚病毒疫苗更常见，在女性比男性更常见，在A/新泽西抗原抗体初始滴度较低的人中更常见。18.7%的疫苗接种者(主要是女性)出现局部炎症，并经常出现全身反应，但与抗体反应无关。新泽西州A/A抗原抗体滴度最初较高，接种后99%的接种者滴度为1：20。A/Victoria抗原抗体效价最初较低，接种后效价为1：20的接种者占56%。在每种病毒的接种者中，大约50%的人的滴度增加了四倍或更多，大多数情况下是同时发生的。对亚病毒疫苗和全病毒疫苗的抗体反应是相似的，高剂量的反应增加与反应原性的增加相一致。由于A/维多利亚抗体滴度较低，以后的复种疫苗产生的抗体反应可以忽略不计。
This placebo-controlled evaluation in elderly persons of inactivated influenza virus vaccines containing 200 or 400 chick cell-agglutinating units of both A/New Jersey/76 and A/Victoria/75 antigens revealed mild systemic reactions in 7.8% and moderate reactions in 4.9% of vaccinees. These reactions were more common after administration of whole-virus than subvirion vaccines, more frequent in females than males, and more frequent in persons with low initial titers of antibody to A/New Jersey antigen. Local inflammation occurred in 18.7% of vaccinees (predominantly females) and frequently was seen with systemic reactions, but did not correlate with antibody response. Titers of antibody to A/New Jersey antigen were initially high, and 99% of vaccinees had titers of >1:20 after vaccination. Titers of antibody to A/Victoria antigen were initially low, and 56% of vaccinees had titers of >1:20 after vaccination. Fourfold or greater increases in titer occurred in about 50% of vaccinees for each virus, most often concomitantly. Antibody responses to subvirion and whole-virus vaccines were similar, and increased responses with higher doses coincided with increased reactogenicity. Later revaccinations because of low titers of A/Victoria antibody produced negligible antibody responses.