The recirculating lymphocyte pool of the rat: a systematic description of the migratory behaviour of recirculating lymphocytes.
The recirculating lymphocyte pool of the rat: a systematic description of the migratory behaviour of recirculating lymphocytes.
复制标题
大鼠的再循环淋巴细胞池：再循环淋巴细胞迁移行为的系统描述。
作者：
M. Smith;W. Ford
在尽可能接近生理状态的条件下，对AO大鼠的淋巴细胞运输进行了全面研究。根据以前的结果，环境因素对淋巴细胞的迁移行为的影响，胸导管细胞通过从血液到淋巴在一个中间的大鼠注射到一系列的收件人进行检查的时间间隔为1分钟至24小时。在1，2和5分钟后，注射大多数标记的细胞在血液中，肺和肝脏。在接下来的25分钟内，随着细胞按照规则模式进入脾脏、淋巴结（LN）和派尔集合淋巴结，这些隔室中的浓度下降。这些器官的峰值定位发生在1小时和18小时之间。每个器官都有淋巴细胞定位的特征性时间模式。淋巴细胞进入肠系膜淋巴结滞后于其他淋巴结，直到注射后2.5小时，随后肠系膜淋巴结的定位容易超过其他淋巴结，在18小时达到延迟的峰值。淋巴细胞从血液进入LN时，穿过高内皮微静脉平均需要5-10分钟。
A comprehensive study of lymphocyte traffic in AO rats was performed under conditions as near to the physiological state as was practicable. In the light of previous results on the effect of environmental factors on the migratory behaviour of lymphocytes, thoracic duct cells were passed from blood to lymph in an intermediate rat before injection into a series of recipients for examination at time intervals from 1 min to 24 hr. At 1, 2 and 5 min after injection most of the labelled cells were in the blood, lungs and liver. The concentrations in these compartments fell over the next 25 min as the cells entered the spleen, lymph nodes (LN) and Peyer's patches according to a regular pattern. The peak localization in these latter organs occurred between 1 hr and 18 hr. Each organ had a characteristic time pattern of lymphocyte localization. Entry into mesenteric LN lagged behind other LN until 2.5 hr after injection following which mesenteric LN localization easily outstripped that in other LN to reach a delayed peak at 18 hr. Intravenously injected lymphocytes began to reappear in thoracic duct lymph in large numbers earlier than in previous studies so that the time taken for most T lymphocytes to cross LN from blood to lymph fell within the broad time band of 4-18 hr. Lymphocytes took on average 5-10 min to cross high endothelial venules when entering LN from the blood.