Phosphoproteins of Oyster ( Crassostrea virginica ) Shell Organic Matrix
Phosphoproteins of Oyster ( Crassostrea virginica ) Shell Organic Matrix
复制标题
牡蛎（Crassostrea virginica）壳有机基质的磷蛋白
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
A. P. Wheeler
中科院分区：
文献类型：
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作者：
A. P. Wheeler
与大多数生物矿物质一样，牡蛎壳是无机晶体和有机基质的复合材料。其矿物质主要是方解石碳酸钙，其基质主要由高酸性磷蛋白组成。在软体动物中，这种类型的基质可能仅限于形成叶状微结构的基质。这些磷蛋白形成分子大小的连续体，范围从中等分子量的可溶性蛋白质到不溶性复合物。事实上，在不同大小的类别中可以鉴定出相似的序列甚至肽，这表明所有类别可能具有共同的前体。主要反相 HPLC 级分的一级结构大致类似于牙齿牙本质的磷蛋白，因为它包含富含天冬氨酸的结构域、富含磷酸丝氨酸的其他结构域和末端疏水结构域。在高离子强度下，蛋白质对晶核和方解石晶体具有高亲和力，但对钙没有高亲和力。根据这些活性，推测不溶性络合物结合核，引发晶体或晶体层生长，并且可溶性组分吸附到晶体表面，从而控制晶体形态并限制晶体生长。
As in most biominerals, the oyster shell is a composite of inorganic crystals and an organic matrix. Its mineral is primarily calcitic calcium carbonate and its matrix is made up largely of highly acidic phosphoproteins. Among molluscs, this type of matrix may be confined to those which form the foliated microstructure. These phosphoproteins form a continuum of molecular sizes ranging from modest molecular weight soluble proteins to insoluble complexes. The fact that similar sequences or even peptides can be identified among the various size classes suggests that all the classes may have common precursors. The primary structure of the major reverse phase HPLC fraction is roughly analogous to the phosphoryns of tooth dentin, in that it contains domains enriched in aspartic acid, other domains enriched in phosphoserine, and a terminal hydrophobic domain. The proteins have high affinities for crystal nuclei and calcite crystals, but not calcium, at high ionic strength. From these activities, it is hypothesized that the insoluble complexes bind nuclei, initiating crystal or crystal layer growth, and that the soluble components adsorb to crystal surfaces and, thereby, both control crystal morphology and limit crystal growth.
DOI：
10.1016/s0174-173x(81)80019-2
发表时间：
1981
期刊：
Collagen and related research
影响因子：
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作者：
Butler,WT;Bhown,M;Dimuzio,MT;Linde,A
通讯作者：
Linde,A