Ongoing burden of disease and mortality from HIV/CMV coinfection in Africa in the antiretroviral therapy era.
Ongoing burden of disease and mortality from HIV/CMV coinfection in Africa in the antiretroviral therapy era.
复制标题
DOI：
10.3389/fmicb.2015.01016
复制
发表时间：
2015
影响因子：
5.2
通讯作者：
Matthews PC
中科院分区：
文献类型：
--
作者：
Adland E;Klenerman P;Goulder P;Matthews PC
人巨细胞病毒（CMV）是一种公认的病原体在艾滋病毒感染的情况下，但由于推出的ART，临床和科学的兴趣在艾滋病毒/CMV合并感染的问题已经减少。然而，CMV仍然是HIV疾病的重要辅助因子，对HIV感染、疾病进展、发病率和死亡率有影响。疾病表现可能是两种病毒之间直接相互作用的结果，也可能是免疫失调和全身炎症的继发结果。当合并感染率很高时，特别是在撒哈拉以南非洲，以及在儿童生命早期有可能感染这两种疾病时，这个问题就显得尤为重要。了解这些病毒之间的相互作用并制定诊断，治疗和预防CMV的策略应该是优先事项。
Human Cytomegalovirus (CMV) is a well-recognized pathogen in the context of HIV infection, but since the roll out of ART, clinical and scientific interest in the problem of HIV/CMV coinfection has diminished. However, CMV remains a significant cofactor in HIV disease, with an influence on HIV acquisition, disease progression, morbidity, and mortality. Disease manifestations may be a result of direct interplay between the two viruses, or may arise as a secondary consequence of immune dysregulation and systemic inflammation. The problem is most relevant when the rates of coinfection are high, most notably in sub-Saharan Africa, and in children at risk of acquiring both infections early in life. Understanding the interplay between these viruses and developing strategies to diagnose, treat and prevent CMV should be a priority.