EXPERIENCE WITH 732 ACUTE OVERDOSE PATIENTS ADMITTED TO AN INTENSIVE-CARE UNIT OVER 6 YEARS
EXPERIENCE WITH 732 ACUTE OVERDOSE PATIENTS ADMITTED TO AN INTENSIVE-CARE UNIT OVER 6 YEARS
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DOI：
10.5694/j.1326-5377.1993.tb121644.x
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发表时间：
1993-01-04
影响因子：
11.4
通讯作者：
POND, SM
中科院分区：
文献类型：
--
作者：
HENDERSON, A;WRIGHT, M;POND, SM
目的：确定急性药物过量患者需要入住重症监护室（ICU）的结果。设计：前瞻性调查所有药物过量患者入住ICU的时间超过6年，截止1991年1月。设置：三级转诊成人教学医院。患者：732例连续急性药物过量患者。结果测量：死亡率，机械通气的使用和持续时间，采取的化合物和化合物的类型与致命outcome.Results：732例患者占13.8%的所有入院和6%的可用ICU病床天。在截至1990年4月的27个月期间，与急诊科因急性药物过量而入院的所有患者进行比较，结果表明，这些患者中有22%被送入ICU。在入住ICU的患者中，三环类抗抑郁药、苯二氮卓类药物和酒精是最常用的化合物。46.8%的患者服用了一种以上的化合物。79.5%的患者需要机械通气，14例（2%）死亡。结论：急性药物过量是进入ICU的常见原因，但死亡率只有2%。与幸存者服用过量相比，服用致命过量的患者更有可能服用大剂量的单一药物或非药用化合物。
Objective: To determine the outcome in patients with acute overdose requiring admission to the intensive Care Unit (ICU).Design: Prospective survey of all overdose admissions to an ICU over a six-year period ending January 1991.Setting: Tertiary referral adult teaching hospital.Patients: 732 consecutive patients with acute overdose.Outcome measures: Death rate, use and duration of mechanical ventilation, type of compound taken and compounds associated with a fatal outcome.Results: The 732 patients represented 13.8% of all admissions and 6% of the available ICU bed-days. Comparison with all admissions to the Emergency Department for acute overdose over a 27-month period ending April 1990 indicated that 22% of these patients were admitted to the ICU. Among the patients admitted to the ICU, tricyclic antidepressants, benzodiazepines and alcohol were the most frequently used compounds. More than one compound had been taken by 46.8% of the patients. Mechanical ventilation was required in 79.5% of the patients and 14 (2%) died.Conclusions: Acute overdose is a common cause of admission to the ICU but has a mortality rate of only 2%. In contrast to the overdoses taken by survivors, patients taking fatal overdoses are more likely to have taken a large dose of a single drug, or a non-medicinal compound.