Domino coupling relay approach to polycyclic pyrrole-2-carboxylates.
Domino coupling relay approach to polycyclic pyrrole-2-carboxylates.
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DOI：
10.1021/ja053408a
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发表时间：
2005-07
影响因子：
15
通讯作者：
Yoshihiko Yamamoto;H. Hayashi;Tomoaki Saigoku;H. Nishiyama
中科院分区：
文献类型：
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作者：
Yoshihiko Yamamoto;H. Hayashi;Tomoaki Saigoku;H. Nishiyama
溴化亚铜催化的N-苄基烯丙胺、乙醛酸乙酯和末端炔的三组分偶联得到甘氨酸连接的1，6-烯炔，其在铱催化条件下通过新型环异构化/Diels-Alder环加成/脱氢反应进一步转化为多环吡咯-2-羧酸酯。
CuBr2-catalyzed three-component coupling of N-benzylallylamine, ethyl glyoxalate, and terminal alkynes afforded glycine-tethered 1,6-enynes, which were further transformed into polycyclic pyrrole-2-carboxylates via novel cycloisomerization/Diels-Alder cycloaddition/dehydrogenation sequence under iridium-catalyzed conditions.