The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization
The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization
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DOI：
10.1038/s41467-019-13575-7
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发表时间：
2019-12-13
影响因子：
16.6
通讯作者：
Meriaux, S.
中科院分区：
文献类型：
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作者：
Barriere, D. A.;Magalhaes, R.;Meriaux, S.
临床前成像研究提供了一种独特的进入大鼠大脑的途径，使研究超越了人类研究的可能性。不幸的是，这些技术仍然缺乏专用和标准化的神经成像工具，即大脑模板和描述性地图集。在这里，我们展示了两个大鼠脑MRI模板及其相关的灰质，白质和脑脊液概率图，由离体T-2*加权图像（90 μ m各向同性分辨率）和体内T-2*加权图像（150 μ m各向同性分辨率）生成。与这些模板相关联，我们还提供了解剖和功能的3D脑地图集，分别来自Waxholm和Tohoku地图集的合并，以及静息状态功能MRI数据的分析。最后，我们提出了一套完整的临床前MRI参考资源，兼容常用的神经成像软件，用于大鼠脑结构和功能的研究。
Preclinical imaging studies offer a unique access to the rat brain, allowing investigations that go beyond what is possible in human studies. Unfortunately, these techniques still suffer from a lack of dedicated and standardized neuroimaging tools, namely brain templates and descriptive atlases. Here, we present two rat brain MRI templates and their associated gray matter, white matter and cerebrospinal fluid probability maps, generated from ex vivo T-2*-weighted images (90 mu m isotropic resolution) and in vivo T-2-weighted images (150 mu m isotropic resolution). In association with these templates, we also provide both anatomical and functional 3D brain atlases, respectively derived from the merging of the Waxholm and Tohoku atlases, and analysis of resting-state functional MRI data. Finally, we propose a complete set of preclinical MRI reference resources, compatible with common neuroimaging software, for the investigation of rat brain structures and functions.