Biofilm formation on intrauterine devices in patients with recurrent vulvovaginal candidiasis
Biofilm formation on intrauterine devices in patients with recurrent vulvovaginal candidiasis
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DOI：
10.3109/13693780902856626
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发表时间：
2010-02-01
期刊：
影响因子：
2.9
通讯作者：
Paula, Claudete R.
中科院分区：
文献类型：
--
作者：
Auler, Marcos E.;Morreira, Debora;Paula, Claudete R.
生物膜是包裹在聚合物基质中的表面相关细胞的复杂群落。它们附着在固体表面，它们的形成可能受到生长条件和与其他病原体的共同感染的影响。生物膜的存在可以保护微生物免受宿主的防御，并显著降低其对抗真菌药物的敏感性。病原微生物可以在植入装置的惰性表面形成生物膜，如导管、人工心脏瓣膜和宫内节育器（iud）。本研究旨在分析复发性外阴阴道念珠菌病患者宫内节育器表面生物膜的存在，并确定分离的酵母菌对两性霉素B和氟康唑的敏感性。从宫内节育器中检出白色念珠菌，在浮游生长条件下检测，发现白色念珠菌对抗真菌药物敏感。这些结果表明，生物膜在宫内节育器表面的存在是复发性外阴阴道念珠菌病的重要危险因素。
A biofilm is a complex community of surface-associated cells enclosed in a polymer matrix. They attach to solid surfaces and their formation can be affected by growth conditions and co-infection with other pathogens. The presence of biofilm may protect the microorganisms from host defenses, as well as significantly reduce their susceptibility to antifungal agents. Pathogenic microbes can form biofilms on the inert surfaces of implanted devices such as catheters, prosthetic cardiac valves and intrauterine devices (IUDs). The present study was carried out to analyze the presence of biofilm on the surface of intrauterine devices in patients with recurrent vulvovaginal candidiasis, and to determine the susceptibility profile of the isolated yeasts to amphotericin B and fluconazole. Candida albicans was recovered from the IUDs and it was found to be susceptible to the antifungal agents when tested under planktonic growing conditions. These findings indicate the presence of the biofilm on the surface of the IUD as an important risk factor for recurrent vulvovaginal candidiasis.