Hypoconnectivity of Resting-State Networks in Persons with Aphasia Compared with Healthy Age-Matched Adults.
Hypoconnectivity of Resting-State Networks in Persons with Aphasia Compared with Healthy Age-Matched Adults.
复制标题
与健康年龄匹配的成年人相比，失语症患者的静息态网络连接性低下。
DOI：
10.3389/fnhum.2017.00091
复制
发表时间：
2017
影响因子：
2.9
通讯作者：
Sandberg CW
中科院分区：
文献类型：
--
作者：
Sandberg CW
失语症是一种语言障碍，在美国影响超过一百万人。虽然语言功能传统上一直是神经影像学研究的重点，但这一人群的其他认知功能也受到影响，这不仅对这些特定过程有影响，而且对语言和其他认知功能的相互作用也有影响。静息状态功能磁共振成像（rs-fMRI）是一种实用和信息丰富的方式来探索和表征一般认知参与和/或健康在这一人群中，但它目前未得到充分利用。本研究的目的是探讨静息状态网络（RSN）和语义网络的功能连接在7人失语症（PWA）谁是至少6个月后发病相比，11名神经健康的成年人（NHA），以获得更全面的了解失语症的一般认知参与。这些初步的结果表明，PWA表现出低连接的语义网络和所有的RSN的视觉网络除外。与NHA相比，PWA似乎有较少的跨半球和左半球的连接。然而，PWA在语义网络中表现出比NHA更强的联系，这可能表明了补偿机制。重要的是，RSN的连通性似乎随着失语症严重程度的降低而增加，随着病变大小的增加而减少。这些知识有可能通过进一步了解损伤对整个认知系统的影响来改善失语症治疗，这可以指导治疗靶点的选择和促进有利的神经重组以实现功能的最佳恢复。
Aphasia is a language disorder affecting more than one million people in the US. While language function has traditionally been the focus of neuroimaging research, other cognitive functions are affected in this population, which has implications not only for those specific processes but also for the interaction of language and other cognitive functions. Resting state fMRI (rs-fMRI) is a practical and informative way to explore and characterize general cognitive engagement and/or health in this population, but it is currently underutilized. The aim of this study was to explore the functional connectivity in resting state networks (RSNs) and in the semantic network in seven persons with aphasia (PWA) who were at least 6 months post onset compared with 11 neurologically healthy adults (NHA) in order to gain a more comprehensive understanding of general cognitive engagement in aphasia. These preliminary results show that PWA exhibit hypoconnectivity in the semantic network and all RSNs except the visual network. Compared with NHA, PWA appear to have fewer cross- and left-hemispheric connections. However, PWA exhibit some stronger connections than NHA within the semantic network, which could indicate compensatory mechanisms. Importantly, connectivity for RSNs appear to increase with decreasing aphasia severity and decrease with increasing lesion size. This knowledge has the potential to improve aphasia therapy by furthering the understanding of lesion effects on the cognitive system as a whole, which can guide treatment target selection and promotion of favorable neural reorganization for optimal recovery of function.