Regulation by chemokines of circulating dendritic cell precursors, and the formation of portal tract-associated lymphoid tissue, in a granulomatous liver disease.
Regulation by chemokines of circulating dendritic cell precursors, and the formation of portal tract-associated lymphoid tissue, in a granulomatous liver disease.
复制标题
DOI：
10.1084/jem.193.1.35
复制
发表时间：
2001-01-01
影响因子：
15.3
通讯作者：
Matsushima, K
中科院分区：
文献类型：
--
作者：
Yoneyama, H;Matsuno, K;Zhang, Y;Murai, M;Itakura, M;Ishikawa, S;Hasegawa, G;Naito, M;Asakura, H;Matsushima, K
我们研究了不同的树突状细胞（DC）前体从循环到痤疮丙酸杆菌诱导的小鼠肝脏肉芽肿的招聘和作用。在感染过程中，F4/80−B220− CD 11 c + DC前体出现在循环中，迁移到窦周隙，并在新形成的肉芽肿中成熟。募集的DC后来迁移到门脉区与T细胞相互作用，我们称之为“门脉相关淋巴组织”（PALT）。巨噬细胞炎性蛋白1α将血液DC前体吸引到窦状肉芽肿，而次级淋巴器官趋化因子（SLC）将成熟DC吸引到新发现的PALT。抗SLC抗体减少PALT扩张，同时加剧肉芽肿形成。因此，循环DC前体可以迁移到实体器官如肝脏，并参与响应特定趋化因子的肉芽肿反应。
We have studied the recruitment and roles of distinct dendritic cell (DC) precursors from the circulation into Propionibacterium acnes–induced granulomas in mouse liver. During infection, F4/80−B220−CD11c+ DC precursors appeared in the circulation, migrated into the perisinusoidal space, and matured within newly formed granulomas. Recruited DCs later migrated to the portal area to interact with T cells in what we term “portal tract–associated lymphoid tissue” (PALT). Macrophage inflammatory protein 1α attracted blood DC precursors to the sinusoidal granuloma, whereas secondary lymphoid organ chemokine (SLC) attracted mature DCs to the newly identified PALT. Anti-SLC antibody diminished PALT expansion while exacerbating granuloma formation. Therefore, circulating DC precursors can migrate into a solid organ like liver, and participate in the granulomatous reaction in response to specific chemokines.