Ventromedial prefrontal cortex mediates guessing
Ventromedial prefrontal cortex mediates guessing
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DOI：
10.1016/s0028-3932(98)00107-9
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发表时间：
1999-04-01
期刊：
影响因子：
2.6
通讯作者：
Dolan, RJ
中科院分区：
文献类型：
--
作者：
Elliott, R;Rees, G;Dolan, RJ
猜测是日常认知的一个重要组成部分。本研究通过一个简单的纸牌游戏任务结合功能性磁共振成像（fMRI）来检测猜测的神经基础。受试者在四种条件下接受扫描。在两种条件下，他们看到纸牌背面的图像，并且必须猜测纸牌的颜色或花色。在另外两种条件下，他们看到纸牌的正面，并且必须报告纸牌的颜色或花色。与报告相比，猜测与外侧前额叶皮层（右侧多于左侧）、右侧眶额叶皮层、前扣带回、双侧顶下小叶皮层和右侧丘脑的显著激活有关。通过操纵可选结果的数量来增加猜测需求与左侧外侧和内侧眶额叶皮层的激活有关。这些数据表明，虽然简单的二选一猜测依赖于一个广泛的神经系统，包括右侧外侧前额叶皮层的区域，但随着概率性偶然事件变得更加复杂，眶额叶皮层的激活会增加。因此，猜测不仅涉及与工作记忆过程有关的系统，还依赖于眶额叶皮层。这个区域在工作记忆任务中通常不被激活，它的激活可能反映了处理不确定性的额外要求。（C）1999年爱思唯尔科学有限公司。保留所有权利。
Guessing is an important component of everyday cognition. The present study examined the neural substrates of guessing using a simple card-playing task in conjunction with functional magnetic resonance imaging (fMRI). Subjects were scanned under four conditions. In two, they were shown images of the back of a playing card and had to guess either the colour or the suit of the card. In the other two they ware shown the face of a card and had to report either the colour or the suit. Guessing compared to reporting was associated with significant activations in lateral prefrontal cortex (right more than left), right orbitofrontal cortex, anterior cingulate, bilateral inferior parietal cortex and right thalamus. Increasing the guessing demands by manipulating the number of alternative outcomes was associated with activation of the left lateral acid medial orbitofrontal cortex. These data suggest that while simple two choice guessing depends on an extensive neural system including regions of the right lateral prefrontal cortex, activation of orbitofrontal cortex increases as the probabilistic contingencies become more complex. Guessing thus involves not only systems implicated in working memory processes but also depends upon orbitofrontal cortex. This region is not typically activated in working memory tasks and its activation may reflect additional requirements of dealing with uncertainty. (C) 1999 Elsevier Science Ltd. All rights reserved.