Selective transport of ATP across a phospholipid bilayer by a molecular umbrella.
Selective transport of ATP across a phospholipid bilayer by a molecular umbrella.
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通过分子伞选择性运输 ATP 穿过磷脂双层。
DOI：
10.1021/ja0291336
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发表时间：
2003
影响因子：
15
通讯作者：
Regen,StevenL
中科院分区：
文献类型：
--
作者：
Janout,Vaclav;Jing,Bingwen;Staina,IrinaV;Regen,StevenL
将亚精胺的每个初级基团与胆酸进行酰化，然后用活化形式nα，Nδ，Nω-Tri-CBZ-L-精氨酸进行酰化反应，然后氢解，得到了一种结合物(即，1)，它容易地将5-三磷酸腺苷，而不是谷胱甘肽，通过由CBA和CBZ制成的磷脂双层转运
Acylation of each primary group of spermidine with cholic acid, followed by acylation of the secondary amino group using an activated form ofNα,Nδ,Nω-tri-CBZ-l-arginine, and subsequent hydrogenolysis, afforded a conjugate (i.e.,1) which readily transports adenosine 5-triphosphate, but not glutathione, across phospholipid bilayers made from 1-palmitoyl-2-oleyol-sn-glycero-3-phosphocholine and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol.