Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women.
Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women.
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DOI：
10.1186/1471-2407-9-122
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发表时间：
2009-04-24
期刊：
影响因子：
3.8
通讯作者：
Tsugane S
中科院分区：
文献类型：
--
作者：
Ma E;Iwasaki M;Junko I;Hamada GS;Nishimoto IN;Carvalho SM;Motola J Jr;Laginha FM;Tsugane S
多项研究已确定，由于一碳代谢途径中 5,10-亚甲基四氢叶酸还原酶 (MTHFR) 和蛋氨酸合酶 (MTR) 之间的相互作用，膳食中 B 族维生素的摄入量可能与乳腺癌风险相关。然而，B 族维生素摄入量与巴西女性尤其是乳腺癌风险之间的关系尚未得到研究。在巴西圣保罗开展了一项病例对照研究，对象为 458 对年龄匹配的巴西女性。叶酸、维生素 B6 和维生素 B12 的能量调整摄入量源自经过验证的食物频率问卷 (FFQ)。 MTHFR A1298C 和 C677T 以及 MTR A2756G 多态性的基因分型已完成。使用逻辑回归模型计算优势比 (OR) 和 95% 置信区间 (95% CI)。膳食中叶酸、维生素 B6 或维生素 B12 的摄入量以及 MTHFR 多态性均与乳腺癌风险无关。按绝经状态分层的分析显示，绝经前女性叶酸摄入量最高三分位数与乳腺癌风险之间存在显着相关性（OR = 2.17，95% CI：1.23–3.83；Ptrend = 0.010）。 MTR 2756GG 基因型与 2756AA 基因型相比，与更高的乳腺癌风险相关（OR = 1.99，95% CI = 1.01–3.92；Ptrend = 0.801），并且在 MTHFR A1298C 多态性与叶酸（P = 0.024）或维生素 B6（P = 0.043），以及 MTHFR C677T 多态性与叶酸（P = 0.043）或维生素 B12（P = 0.022）之间的差异。 MTHFR 多态性以及叶酸、维生素 B6 和维生素 B12 的饮食摄入量与乳腺癌风险没有总体关联。然而，在所有具有 MTR 2756GG 基因型的女性和叶酸摄入量高的绝经前女性中，观察到风险增加。这些发现以及 MTHFR 多态性和 B 族维生素之间的显着相互作用值得进一步研究。
Several studies have determined that dietary intake of B vitamins may be associated with breast cancer risk as a result of interactions between 5,10-methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR) in the one-carbon metabolism pathway. However, the association between B vitamin intake and breast cancer risk in Brazilian women in particular has not yet been investigated. A case-control study was conducted in São Paulo, Brazil, with 458 age-matched pairs of Brazilian women. Energy-adjusted intakes of folate, vitamin B6, and vitamin B12 were derived from a validated Food Frequency Questionnaire (FFQ). Genotyping was completed for MTHFR A1298C and C677T, and MTR A2756G polymorphisms. A logistical regression model was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). Neither dietary intake of folate, vitamin B6, or vitamin B12 nor MTHFR polymorphisms were independently associated with breast cancer risk. Analysis stratified by menopausal status showed a significant association between placement in the highest tertile of folate intake and risk of breast cancer in premenopausal women (OR = 2.17, 95% CI: 1.23–3.83; Ptrend = 0.010). The MTR 2756GG genotype was associated with a higher risk of breast cancer than the 2756AA genotype (OR = 1.99, 95% CI = 1.01–3.92; Ptrend = 0.801), and statistically significant interactions with regard to risk were observed between the MTHFR A1298C polymorphism and folate (P = 0.024) or vitamin B6 (P = 0.043), and between the MTHFR C677T polymorphism and folate (P = 0.043) or vitamin B12 (P = 0.022). MTHFR polymorphisms and dietary intake of folate, vitamin B6, and vitamin B12 had no overall association with breast cancer risk. However, increased risk was observed in total women with the MTR 2756GG genotype and in premenopausal women with high folate intake. These findings, as well as significant interactions between MTHFR polymorphisms and B vitamins, warrant further investigation.