Adverse health effects related to tobacco smoke exposure in a cohort of three-year olds
Adverse health effects related to tobacco smoke exposure in a cohort of three-year olds
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DOI：
10.1111/j.1651-2227.2007.00619.x
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发表时间：
2008-03-01
期刊：
影响因子：
3.8
通讯作者：
Hermansson, Goeran
中科院分区：
文献类型：
--
作者：
Johansson, AnnaKarin;Ludvigsson, Johnny;Hermansson, Goeran
目的：分析母亲在怀孕期间吸烟和/或儿童早期暴露于环境烟草烟雾 (ETS) 对 3 岁时儿童健康和福祉的重要性。方法：对基于人群的队列 (n = 8850) 中的四组进行比较：怀孕期间母亲不吸烟的儿童和 3 岁时父母不吸烟的儿童 (n = 7091)；仅胎儿暴露的儿童 (n = 149)；仅在出生后暴露的儿童（n = 895）和在产前和产后均暴露的儿童（n = 595）。计算比值比和 95% 置信区间。 结果：产前和产后暴露的儿童出现更多喘息（1.14；1.07-1.21）和鼻炎（1.16；1.06-1.26），使用更多咳嗽合剂（1.07；1.01-1.14）和支气管扩张药物（1.08；1.01-1.14）。与不吸烟父母的孩子相比，他们的孩子更容易哭闹（1.31；1.13-1.51）和易怒（1.27；1.09-1.48）。与不吸烟父母的孩子相比，仅在出生后接触该病毒的孩子患鼻炎的比例更高（1.24；1.12-1.37），使用更多的止咳药（1.14；1.05-1.29），睡眠质量差的比例也更高（1.26；1.07-1.47）。产前暴露的儿童仅使用更多的支气管扩张药物（1.45；1.03-2.04），并且睡眠质量差的情况也更严重（2.06；1.09-3.87）。
Aim: To analyse the importance of mothers' smoking during pregnancy and/or environmental tobacco smoke (ETS) exposure in early childhood for children's health and well-being at the age of 3 years.Methods: Four groups from a population based cohort (n = 8850) were compared: children with nonsmoking mother during pregnancy and nonsmoking parents at the age of 3 years (n = 7091); children with only foetal exposure (n = 149); children exposed only postnatally (n = 895) and children exposed both pre- and postnatally (n = 595). Odds ratios and 95% confidence intervals were calculated.Results: Children exposed both pre- and postnatally had more wheezing (1.14; 1.07-1.21) and rhinitis (1.16; 1.06-1.26), used more cough-mixture (1.07; 1.01-1.14) and broncodilatating drugs (1.08; 1.02-1.15) and suffered more from excessive crying (1.31; 1.13-1.51) and irritability (1.27; 1.09-1.48) compared to children with nonsmoking parents. Children exposed only postnatally had more rhinitis (1.24; 1.12-1.37), used more cough-mixture (1.14; 1.05-1.29) and suffered more from poor sleep (1.26; 1.07-1.47) than children of nonsmoking parents. Children with prenatal exposure only used more broncodilatating drugs (1.45; 1.03-2.04) and suffered more from poor sleep (2.06; 1.09-3.87).