Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells
Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells
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DOI：
10.4049/jimmunol.180.5.2752
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发表时间：
2008-03-01
影响因子：
4.4
通讯作者：
Ghilardi, Nico
中科院分区：
文献类型：
--
作者：
Batten, Marcel;Kljavin, Noelyn M.;Ghilardi, Nico
细胞因子IL-27对于在应对各种免疫挑战时限制炎症反应非常重要。在这项研究中，我们证明了IL-27通过CD4(+)和CD8(+)T细胞诱导抗炎细胞因子IL-10的表达。IL-27依赖Th1转录因子STAT1诱导IL-10(+)干扰素-γ(+)FoxP3(-)Th1细胞，最近发现在某些感染过程中，这些细胞是关键的负调控因子。IL27ra(-/-)小鼠在单核细胞增多性李斯特菌感染和实验性自身免疫性脑脊髓炎期间产生的IL-10(+)T细胞较少。这些数据表明了T细胞诱导IL-10表达的新机制，并为IL-27的抑制作用提供了机制基础。
The cytokine IL-27 is important for restricting inflammation in response to a wide variety of immune challenges. In this study, we demonstrate that IL-27 induces expression of the anti-inflammatory cytokine IL-10 by CD4(+) and CD8(+) T cells. IL-27 relied upon the Th1 transcription factor STAT1 to induce IL-10(+)IFN-gamma(+)FoxP3(-) Th1 cells, which were recently shown to be key negative regulators during certain infections. IL27ra(-/-) mice generated fewer IL-10(+) T cells during both Listeria monocytogenes infection and experimental autoimmune encephalomyelitis. The data presented here indicate a novel mechanism for the induction of IL-10 expression by T cells and provide a mechanistic basis for the suppressive effects of IL-27.