On the role of electric field orientation in optimal design of transcranial current stimulation.
On the role of electric field orientation in optimal design of transcranial current stimulation.
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DOI：
10.1109/embc.2012.6347465
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Parra LC
中科院分区：
文献类型：
--
作者：
Dmochowski JP;Bikson M;Datta A;Richardson J;Fridriksson J;Parra LC
经颅电流刺激（TCS）是一种很有前途的非侵入性技术，通过头皮电极传递微弱的电流来引起神经调节。虽然已经致力于设计将电流“引导”到感兴趣区域的刺激方案，但是以前的工作几乎完全集中在电场的大小上，而忽略了方向的影响。尽管先前的体外研究表明场取向和细胞对称轴之间的角度对可能潜在的治疗效果的所得膜极化具有显著影响。为此，在这里，我们研究了所需的电场方向对给定目标区域的电极的最佳放置的影响。基于高分辨率的头部模型，来自磁共振扫描的患者参加了临床试验，检查使用TCS在中风后康复，我们推导出并采用了优化算法，计算蒙太奇最大化定向电流在目标。结果表明，强烈依赖于所需的方向上的最佳蒙太奇，此外，在目标区域的感应电场的大小变化很大的首选方向。这表明，识别感兴趣区域处的期望电场方向是合理电刺激范例开发中的关键步骤。
Transcranial current stimulation (tCS) is a promising noninvasive technique to elicit neuromodulation by passing weak electrical currents through scalp electrodes. While significant effort has been devoted towards designing stimulation protocols which “steer” current to regions of interest, previous work has been almost exclusively focused on the magnitude of the electric field, while ignoring the effects of direction. This is despite previous in vitro studies demonstrating that the angle between the field orientation and the cell axis of symmetry has significant effects on the resulting membrane polarization presumably underlying therapeutic effects. To that end, here we examine the impact of the desired electric field orientation on the optimal placement of electrodes for a given target region. Based on high-resolution head models derived from magnetic resonance scans of patients enrolled in a clinical trial examining the use of tCS in rehabilitation after stroke, we derive and employ an optimization algorithm which computes the montage maximizing directed current flow at the target. The results reveal a strong dependence of the optimal montage on the desired orientation; moreover, the magnitude of the induced electric field at the target region varies widely with the preferred direction. This suggests that identifying the desired electric field orientation at the region of interest is a crucial step in the development of rational electrical stimulation paradigms.