Fruit and vegetable intakes are associated with lower risk of breast fibroadenomas in Chinese women.
Fruit and vegetable intakes are associated with lower risk of breast fibroadenomas in Chinese women.
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DOI：
10.3945/jn.109.119719
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发表时间：
2010-07
期刊：
影响因子：
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通讯作者：
Zakia Coriaty Nelson;R. Ray;Chunyuan Wu;H. Stalsberg;P. Porter;J. Lampe;J. Shannon;N. Horner;Wenjin Li;Wen-wan Wang;Yong-wei Hu;D. Gao;D. Thomas
中科院分区：
文献类型：
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作者：
Zakia Coriaty Nelson;R. Ray;Chunyuan Wu;H. Stalsberg;P. Porter;J. Lampe;J. Shannon;N. Horner;Wenjin Li;Wen-wan Wang;Yong-wei Hu;D. Gao;D. Thomas
纤维腺瘤是女性常见的良性乳腺疾病，约占乳腺活检的50%。众所周知，饮食因素会影响良性乳腺疾病的总体情况，但很少有人知道他们的协会，特别是与纤维腺瘤。本研究的目的是评估饮食和其他因素与纤维腺瘤风险之间的关系。1989年至2000年，在中国上海的纺织工人中进行了一项乳腺自我检查（BSE）随机试验的病例对照研究。研究样本包括327名受影响的妇女和1070名对照。对妇女进行了FFQ和问卷调查，以了解生殖和妇科史及其他信息。比值比作为相对危险度的估计值，采用多变量条件Logistic回归计算。纤维腺瘤风险的显著下降趋势与水果和蔬菜的摄入量和活产的数量有关，风险的降低也与自然绝经、口服避孕药的使用和适度运动（散步和园艺）有关。纤维腺瘤的风险增加与20多岁时的重体力活动、一级亲属患乳腺癌以及先前的良性乳房肿块病史有关;并且观察到风险的显著增加趋势与每年的BSE数量和受教育年限有关。总之，富含水果和蔬菜的饮食和口服避孕药的使用可以降低纤维腺瘤的风险。
Fibroadenomas are common benign breast conditions among women and account for approximately 50% of breast biopsies performed. Dietary factors are known to influence benign breast conditions in the aggregate, but little is known of their association specifically with fibroadenoma. Our objective in this study was to evaluate the association between dietary and other factors and fibroadenoma risk. A case-control study, nested in a randomized trial of breast self-examination (BSE) in Chinese textile workers in Shanghai, China, was conducted between 1989 and 2000. The study sample included 327 affected women and 1070 controls. Women were administered a FFQ and a questionnaire that elicited reproductive and gynecological history and other information. Odds ratios, as estimates of relative risks, were calculated using multivariate conditional logistic regression. Significant decreasing trends in risk of fibroadenoma were observed with intake of fruits and vegetables and with number of live births, and a reduced risk was also associated with natural menopause, oral contraceptive use, and moderate exercise (walking and gardening). Increased risk of fibroadenoma was associated with heavy physical activity in one's 20s, breast cancer in a first-degree relative, and a history of prior benign breast lumps; and significant increasing trends in risk were observed with numbers of BSE per year and years of education. In conclusion, a diet rich in fruits and vegetables and the use of oral contraceptives may reduce risk of fibroadenoma.