Modulation of immune cell function by α(1)-adrenergic receptor activation.
Modulation of immune cell function by α(1)-adrenergic receptor activation.
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通过α（1） - 肾上腺素受体激活调节免疫细胞功能。
DOI：
10.1016/b978-0-12-384921-2.00006-9
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发表时间：
2011
影响因子：
--
通讯作者：
Porter, James E.
中科院分区：
文献类型：
--
作者：
Grisanti, Laurel A.;Perez, Dianne M.;Porter, James E.
交感神经系统通过肾上腺素（Epi）和去甲肾上腺素（NE）激活免疫活性细胞群上表达的肾上腺素能受体（AR）来调节人类免疫系统功能。最常归因于交感神经活性增加的抗炎作用已被证明通过β2-和α2-AR刺激发生。然而，AR对免疫系统功能的二分作用正变得越来越明显。由于缺乏特异性抗体或亚型选择性受体配体，α1-AR在免疫细胞群上表达的报道一直相互矛盾。这使得α1-AR鉴定困难，并且限制了α1-AR亚型表达的进一步表征。然而，有一些证据表明，在某些生理条件和疾病状态下，α1-AR在免疫活性细胞上的表达被诱导。此外，α1-AR激活调节免疫应答的功能在文献中刚刚开始出现。已经描述了α1-AR刺激免疫活性细胞后炎症介质分泌的变化以及细胞迁移和分化的增加。这些观察结果证明了α1-AR活性在免疫细胞生物学中的重要性，并强调了了解α1-AR对免疫系统作用的重要性。
The sympathetic nervous system regulates human immune system functions through epinephrine (Epi) and norepinephrine (NE) activation of adrenergic receptors (AR) expressed on immunocompetent cell populations. The anti-inflammatory effects that are most often attributed to increased sympathetic activity have been shown to occur through β2- and α2-AR stimulation. However, dichotomous AR effects on immune system function are becoming increasingly apparent. Reports of α1-AR expression on immune cell populations have been conflicting due to a lack of specific antibodies or subtype-selective receptor ligands. This has made α1-AR identification difficult and further characterization of α1-AR subtype expression limited. Nevertheless, there is some evidence suggesting an induction of α1-AR expression on immunocompetent cells under certain physiological conditions and disease states. Also, the function of α1-AR activation to modulate immune responses is just beginning to emerge in the literature. Changes in the secretion of inflammatory mediators as well as increased cell migration and differentiation have been described following α1-AR stimulation on immunocompetent cells. These observations demonstrate the significance of α1-AR activity in immune cell biology and emphasize the importance for understanding α1-AR effects on the immune system.