Maternal and early life exposure to phthalates: The Plastics and Personal-care Products use in Pregnancy (P4) study
Maternal and early life exposure to phthalates: The Plastics and Personal-care Products use in Pregnancy (P4) study
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DOI：
10.1016/j.scitotenv.2016.02.022
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发表时间：
2016-05-01
影响因子：
9.8
通讯作者：
Tawagi, George
中科院分区：
文献类型：
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作者：
Arbuckle, Tye E.;Fisher, Mandy;Tawagi, George
邻苯二甲酸酯是一组在许多消费品中发现的化学物质;其中一些邻苯二甲酸酯已被证明具有雌激素活性并显示抗雄激素作用。虽然已经发表了一些关于孕妇和婴儿邻苯二甲酸酯的生物监测研究，但基于多个采样期和不同基质的数据很少。在加拿大渥太华（2009-2010年）的80名孕妇及其婴儿中测量了分娩前后不同时间段收集的尿液、胎粪和母乳中的邻苯二甲酸酯代谢物。至少50%的女性至少有一个尿液样本大于各种邻苯二甲酸酯代谢物的检测限（LOD），但邻苯二甲酸单正辛酯（MnOP）、邻苯二甲酸单异壬酯（MiNP）和邻苯二甲酸单（羧基异辛酯）（MCiOP）除外。确定了母体尿液代谢物的四个主要簇。在婴儿（n = 61）中，很少（< 10%）检测到以下代谢物：邻苯二甲酸单环己酯（MCHP）、邻苯二甲酸单异壬酯（MiNP）、邻苯二甲酸单甲酯（MMP）和邻苯二甲酸单正辛酯（MnOP）。虽然邻苯二甲酸单苄酯（MBzP）、邻苯二甲酸单-3-羧丙酯（MCPP）、MEHHP和MEOHP在任何时间点均经常在母体尿液中检出，但在母乳中很少检出这些代谢物。在妊娠期间采集的样本中，MEP和DEHP代谢物的母体尿液浓度高于出生后。母乳喂养和人工喂养婴儿的尿邻苯二甲酸酯浓度无统计学显著差异。孕妇尿MEHHP（r = 0.35）、MEOHP（r = 0.35）和MEP（r = 0.37）之间存在显著相关性，
Phthalates are a group of chemicals found in a number of consumer products; some of these phthalates have been shown to possess estrogenic activity and display anti-androgenic effects. While a number of biomonitoring studies of phthalates in pregnant women and infants have been published, there is a paucity of data based on both multiple sampling periods and in different matrices. Phthalate metabolites were measured in 80 pregnant women and their infants in Ottawa Canada (2009-2010) in urine, meconium and breast milk collected at various time periods pre- and post-parturition. At least 50% of the women had at least one urine sample greater than the limit of detection (LOD) for the various phthalate metabolites, with the exception of mono-n-octyl phthalate MnOP), mono-isononyl phthalate (MiNP) and mono(carboxy-isooctyl) phthalate (MCiOP). Four major clusters of maternal urinary metabolites were identified. Among infants (n = 61), the following metabolites were rarely (< 10%) detected: mono-cyclohexyl phthalate (MCHP), mono-isononyl phthalate (MiNP), mono-methyl phthalate (MMP), and mono-n-octyl phthalate (MnOP). While mono-benzyl phthalate (MBzP), mono-3-carboxypropyl phthalate (MCPP), MEHHP, and MEOHP were frequently detected in maternal urines at any time point, these metabolites were rarely detected in breast milk. Maternal urinary concentrations of MEP and the DEHP metabolites were higher in samples collected during pregnancy than postnatally. No statistically significant differences were observed in infant's urinary phthalate concentrations between breast-fed and bottle-fed infants. Significant correlations were observed between maternal urinary MEHHP (r = 0.35), MEOHP (r = 0.35) and MEP (r = 0.37) collected at