Entrainment of Syrian hamster circadian activity rhythms by neonatal melatonin injections.
Entrainment of Syrian hamster circadian activity rhythms by neonatal melatonin injections.
复制标题
新生儿褪黑激素注射诱导叙利亚仓鼠昼夜节律活动。
DOI：
10.1152/ajpregu.1996.270.3.r533
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Davis,FC
中科院分区：
文献类型：
--
作者：
Grosse,J;Velickovic,A;Davis,FC
啮齿动物的胎儿和新生儿的昼夜节律是由他们的母亲。这种夹带依赖于母体视交叉上核（SCN），但夹带的机制尚不清楚。给怀孕的SCN损伤的雌性叙利亚仓鼠注射松果体激素褪黑激素，可以诱导仓鼠幼崽的活动节律。本研究的目的是确定是否褪黑激素直接注射在新生的叙利亚仓鼠是能够夹带昼夜节律，如果是这样，这种效果持续多长时间在发展过程中。注射褪黑激素在两组仓鼠幼崽在出生后1-5天相反的阶段夹带的活动节律的发病日断奶的两个阶段，相隔10.67小时。褪黑激素注射没有夹带活动节律相反的阶段，无论是出生后6-10天或21-25。在研究的任何年龄，溶媒注射均未将动物带入相反阶段。这些结果表明，褪黑激素能够直接作用于新生儿，导致夹带，这种影响在出生后第6天消失。
The circadian rhythms of fetal and neonatal rodents are entrained by their mother. This entrainment is dependent upon the maternal suprachiasmatic nucleus (SCN), but the mechanism of entrainment is unknown. Administration of the pineal hormone melatonin to pregnant, SCN-lesioned female Syrian hamsters entrains the activity rhythms of their hamster pups. The aim of this study was to determine whether melatonin injected directly in neonatal Syrian hamsters is able to entrain circadian rhythms and, if so, for how long this effect persists during development. Injection of melatonin in two groups of hamster pups at opposite phases on postnatal days 1-5 entrained the onset of activity rhythms on the day of weaning to two phases 10.67 h apart. Melatonin injection did not entrain activity rhythms to opposite phases on either postnatal days 6-10 or 21-25. Vehicle injection did not entrain animals to opposite phases at any of the ages studied. These results demonstrate that melatonin is able to act directly on the neonate to cause entrainment and that this effect disappears after postnatal day 6.