A Possible Unitary Genetic Hypothesis for Alzheimer's Disease and Down Syndrome a
A Possible Unitary Genetic Hypothesis for Alzheimer's Disease and Down Syndrome a
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阿尔茨海默病和唐氏综合症的可能单一遗传假说
DOI：
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发表时间：
1985
影响因子：
5.2
通讯作者：
M. Schweber
中科院分区：
文献类型：
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作者：
M. Schweber
阿尔茨海默氏病表现在三重疾病分类学上：解剖学、生物化学和行为学。许多报告发现阿尔茨海默病和唐氏综合症在所有三个层面上都有相似之处和相互关系，以及流行病学关联。唐氏综合症和阿尔茨海默病之间明显的关系是否可以反映出机制上的相似性，这似乎是合乎逻辑的。也就是说，通过考虑阿尔茨海默氏病与唐氏综合症具有相似的因果关系这一假设，是否可以获得对该疾病的病因学和病理生理学的可检验的见解。鉴于唐氏综合症是一种其遗传因果关系已得到充分表征的疾病，问题是阿尔茨海默氏病是否可能涉及任何遗传相似性。
Alzheimer’s disease is expressed in a three-fold nosology: anatomic, biochemical, and behavioral. Numerous reports have found similarities and interrelationships between Alzheimer’s disease and Down syndrome on all three levels, and epidemiological associations as well. It seems logical to ask whether the demonstrable relationship between Down syndrome and Alzheimer’s disease could reflect any similarity in mechanisms; that is, whether testable insights can be gained for both the etiology and pathophysiology of Alzheimer’s disease by considering the hypothesis that the disease shares a similarity of causality with Down syndrome Given that Down syndrome is a disorder whose genetic causality is well characterized, the question is whether Alzheimer’s disease may involve any genetic similarities.
阿尔茨海默病大脑：RNA 水平和核糖核酸酶抑制剂复合物的变化。
DOI：
10.1126/science.6206567
发表时间：
1984
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Sajdel-Sulkowska,EM;Marotta,CA
通讯作者：
Marotta,CA