Prediction of airway deformation effect on pulmonary air-particle dynamics: A numerical study
Prediction of airway deformation effect on pulmonary air-particle dynamics: A numerical study
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DOI：
10.1063/5.0065309
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发表时间：
2021-10
影响因子：
4.6
通讯作者：
Jianan Zhao;Yu Feng;K. Koshiyama;Hui-Chun Wu
中科院分区：
文献类型：
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作者：
Jianan Zhao;Yu Feng;K. Koshiyama;Hui-Chun Wu
现有的全肺模型大多忽略气道的变形运动学，认为肺气道是静态的。然而，忽略气道变形对肺空气颗粒流动动力学的影响，严重限制了在疾病特异性肺条件下的建模能力。为此，采用单向耦合欧拉-拉格朗日法和动态网格法，建立了一种新型的弹性截短全肺（TWL）模型框架，以模拟疾病特异性气道变形运动学与肺空气颗粒流动动力学同时进行。具体而言，使用健康肺和慢性阻塞性肺疾病（COPDs）肺的临床数据和肺功能测试结果校准弹性TWL模型的变形运动学。研究了球形亚微米粒子和微米粒子的输运动力学。结果表明，静态肺模型和弹性肺模型在空气颗粒流动预测上存在显著差异，这表明在全肺模型中建立气道变形运动学模型的必要性。弹性TWL模型预测口喉区沉积分数较低，下气道沉积分数较高。研究了疾病特异性气道变形运动学对颗粒在全肺中的运输和沉积的影响，重点研究了小气道从第一代（G8）到肺泡的靶向药物递送效率，肺泡是使用吸入疗法治疗COPD的指定肺部位。模拟结果表明，随着COPD病情的加重，吸入药物颗粒的最高递送效率降低，这表明对于病情严重的患者来说，将雾化药物递送到小气道治疗COPD更具挑战性。由AIP出版社独家授权出版。https://doi.org/10.1063/5.0065309
Most existing whole lung models neglect the airway deformation kinematics and assume the lung airways are static. However, neglecting the airway deformation effect on pulmonary air-particle flow dynamics significantly limits the modeling capability under disease-specific lung conditions. Therefore, a novel elastic truncated whole-lung (TWL) modeling framework has been developed to simulate the disease-specific airway deformation kinematics simultaneously with pulmonary air-particle flow dynamics using one-way coupled Euler–Lagrange method plus the dynamic mesh method. Specifically, the deformation kinematics of the elastic TWL model was calibrated with clinical data and pulmonary function test results for both healthy lung and lungs with chronic obstructive pulmonary diseases (COPDs). The transport dynamics of spherical sub micrometer and micrometer particles were investigated. Results show that noticeable differences in air-particle flow predictions between static and elastic lung models can be found, which demonstrates the necessity to model airway deformation kinematics in whole-lung models. The elastic TWL model predicted lower deposition fraction in mouth-throat regions and higher deposition fraction in lower airways. The effect of disease-specific airway deformation kinematics on particle transport and deposition in the whole lung was investigated, with a focus on the targeted drug delivery efficiency in small airways from generation (G8) to alveoli as the designated lung sites for COPD treatment using inhalation therapy. Simulation results indicate that with the exacerbation of COPD disease conditions, the highest delivery efficiency of the inhaled drug particles decreases which indicates that delivering aerosolized medications to small airways to treat COPD is more challenging for patients with severe disease conditions. Published under an exclusive license by AIP Publishing. https://doi.org/10.1063/5.0065309