Validation of an accurate and expedient initial rates method for characterizing mechanophore reactivity
Validation of an accurate and expedient initial rates method for characterizing mechanophore reactivity
复制标题
验证用于表征机械载体反应性的准确且便捷的初始速率方法
DOI：
10.1021/acsmacrolett.3c00054
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发表时间：
2023
影响因子：
7.015
通讯作者：
Robb, Maxwell J.
中科院分区：
文献类型：
--
作者：
McFadden, Molly E.;Overholts, Anna C.;Osler, Skylar K.;Robb, Maxwell J.
理解结构-机械化学反应性关系对于通知新的刺激响应聚合物的合理设计是重要的。为此，建立准确的反应动力学的机械活化是一个关键目标。在这里，我们验证了初始速率的方法，使准确和快速的确定超声诱导的机械化学转化的速率常数。实验反应曲线与理论模型一致，这支持初始速率方法有效地将非特异性断链的竞争过程中特定机械活性团活化的动力学解卷积。
Understanding structure–mechanochemical reactivity relationships is important for informing the rational design of new stimuli-responsive polymers. To this end, establishing accurate reaction kinetics for mechanophore activation is a key objective. Here, we validate an initial rates method that enables the accurate and rapid determination of rate constants for ultrasound-induced mechanochemical transformations. Experimental reaction profiles are well-aligned with theoretical models, which support that the initial rates method effectively deconvolutes the kinetics of specific mechanophore activation from the competitive process of nonspecific chain scission.