LAMINATED 3-DIMENSIONAL BIODEGRADABLE FOAMS FOR USE IN TISSUE ENGINEERING
LAMINATED 3-DIMENSIONAL BIODEGRADABLE FOAMS FOR USE IN TISSUE ENGINEERING
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DOI：
10.1016/0142-9612(93)90049-8
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发表时间：
1993-04-01
期刊：
影响因子：
14
通讯作者：
LANGER, R
中科院分区：
文献类型：
--
作者：
MIKOS, AG;SARAKINOS, G;LANGER, R
报道了一种新的加工技术，用于构建具有精确解剖形状的三维可生物降解聚合物泡沫。该技术涉及孔隙率高达90%的高度多孔膜的层压。制备了由聚（L-乳酸）和聚（DL-乳酸-共-乙醇酸）共聚物制成的特定形状的植入物，以评估可行性。所产生的生物材料具有与构成膜的孔形态相似的孔形态。层压装置的相邻层的孔是互连的，从而产生连续的孔结构。多层器件的压缩蠕变行为也类似于单个层的压缩蠕变行为。我们小组和其他人最近发现，使用在合成的生物可降解聚合物上培养的细胞可以再生和重建器官和组织，这使得这种方法在创建用于细胞移植的聚合物细胞移植物中是有用的。
A novel processing technique is reported to construct three-dimensional biodegradable polymer foams with precise anatomical shapes. The technique involved the lamination of highly-porous membranes of porosities up to 90%. Implants with specific shapes were prepared made of poly(L-lactic acid) and copolymers of poly(DL-lactic-co-glycolic acid) to evaluate feasibility. The biomaterials produced have pore morphologies similar to those of the constituent membranes. The pores of adjacent layers of laminated devices are interconnected, resulting in continuous pore structures. The compressive creep behaviour of multilayered devices is also similar to that of the individual layers. Recent discoveries from our group and others that organs and tissues can be regenerated and reconstructed, using cells cultured on synthetic biodegradable polymers, renders this method useful in creating polymer-cell grafts for use in cell transplantation.