Radiation and Thyroid Cancer.
Radiation and Thyroid Cancer.
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DOI：
10.3390/ijms18050911
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发表时间：
2017-04-26
影响因子：
5.6
通讯作者：
Curcio F
中科院分区：
文献类型：
--
作者：
Albi E;Cataldi S;Lazzarini A;Codini M;Beccari T;Ambesi-Impiombato FS;Curcio F
辐射损伤是一个相互关联的信号通路的复杂网络，可能导致细胞凋亡、细胞周期停滞、DNA修复和癌症。甲状腺癌对辐射的反应，从核灾难到化疗，长期以来一直是研究的对象。对甲状腺的敏感性对辐射和癌症发展的电离和非电离辐射效应进行了基本概述。在这篇综述中，我们把注意力集中在细胞培养中暴露在电离辐射、紫外线和质子束中的实验。有关特定基因、蛋白质和脂类参与的研究也有报道。这篇综述还描述了如何调节脂质以应对辐射损伤，以及它们如何参与甲状腺癌的病因、侵袭和转移，以及它们如何被用作诊断标记物和药物靶点。
Radiation-induced damage is a complex network of interlinked signaling pathways, which may result in apoptosis, cell cycle arrest, DNA repair, and cancer. The development of thyroid cancer in response to radiation, from nuclear catastrophes to chemotherapy, has long been an object of study. A basic overview of the ionizing and non-ionizing radiation effects of the sensitivity of the thyroid gland on radiation and cancer development has been provided. In this review, we focus our attention on experiments in cell cultures exposed to ionizing radiation, ultraviolet light, and proton beams. Studies on the involvement of specific genes, proteins, and lipids are also reported. This review also describes how lipids are regulated in response to the radiation-induced damage and how they are involved in thyroid cancer etiology, invasion, and migration and how they can be used as both diagnostic markers and drug targets.