A Brief Update on STAT3 Signaling: Current Challenges and Future Directions in Cancer Treatment
A Brief Update on STAT3 Signaling: Current Challenges and Future Directions in Cancer Treatment
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DOI：
10.33696/signaling.2.050
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发表时间：
2021-09
期刊：
影响因子：
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通讯作者：
K. Taniguchi;M. Tsugane;A. Asai
中科院分区：
文献类型：
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作者：
K. Taniguchi;M. Tsugane;A. Asai
由于其在包括细胞增殖、细胞凋亡和免疫逃避在内的广泛细胞过程中的重要性，在过去的几十年里，转录信号换能器和激活器（STAT） 3信号通路得到了广泛的研究。STAT3信号通路的失调与各种类型的血液或实体恶性肿瘤（约70%出现在人类中）的发生和发展密切相关。
Due to its importance in a wide range of cellular processes, including cell proliferation, apoptosis, and immune evasion, the signal transducer and activator of transcription (STAT) 3 signaling pathway has been studied intensively over the past few decades. Dysregulation of the STAT3 signaling pathway is closely associated with initiation and development of various types of hematologic or solid malignancies (approximately 70% of those appearing in humans) [1].