Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas
Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas
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DOI：
10.1016/j.canlet.2006.05.001
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发表时间：
2007-03-18
期刊：
影响因子：
9.7
通讯作者：
Ushijima, Toshikazu
中科院分区：
文献类型：
--
作者：
Abe, Masanobu;Westermann, Frank;Ushijima, Toshikazu
在我们之前的研究中，CpG岛甲基化表型（ClMP）与日本神经母细胞瘤（NBL）病例的总生存率（OS）低密切相关。这里，在德国NBL病例中，CIMP（+）病例（n = 95）的OS明显较差(风险比(HR) = 9.5；P < 0.0001)和无病生存期（DFS） （HR = 5.4; P < 0.0001）均优于CIMP（-）病例（n = 50）。23例N-myc扩增均为CIMP。在其余无n -myc扩增的病例中，CIMP（+）病例（27例）的OS （HR = 4.5, P = 0.02）和DFS （HR = 5.2, P < 0.0001）较CIMP（-）病例（n = 95）差。在多因素分析中，CIMP和N-myc扩增对OS和DFS的影响与年龄和疾病分期无关。CIMP对DFS的影响强于N-myc扩增，而N-myc对OS的影响更强。2006爱思唯尔爱尔兰有限公司版权所有。
The CpG island methylator phenotype (ClMP) was closely associated with poor overall survival (OS) in Japanese neuroblastoma (NBL) cases in our previous study. Here, in German NBL cases, CIMP(+) cases (n = 95) showed markedly poorer OS (hazard ratio (HR) = 9.5; P < 0.0001) and disease-free survival (DFS) (HR = 5.4; P < 0.0001) than CIMP(-) cases (n = 50). All the 23 cases with N-myc amplification had CIMP. Among the remaining cases without N-myc amplification, CIMP(+) cases (n 27) had a poorer OS (HR = 4.5; P = 0.02) and DFS (HR = 5.2; P < 0.0001) than CIMP(-) cases (n = 95). In multivariate analysis, CIMP and N-myc amplification had an influence on OS and DFS independent of age and disease stage. CIMP had a stronger influence on DFS than N-myc amplification while N-myc had a stronger influence on OS. (c) 2006 Elsevier Ireland Ltd. All rights reserved.