ROLE OF BRAIN NOREPINEPHRINE IN ANOREXIC EFFECTS OF DEXTROAMPHETAMINE AND MONOAMINE OXIDASE INHIBITORS IN RAT
ROLE OF BRAIN NOREPINEPHRINE IN ANOREXIC EFFECTS OF DEXTROAMPHETAMINE AND MONOAMINE OXIDASE INHIBITORS IN RAT
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DOI：
10.1007/bf00403623
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发表时间：
1971-01-01
期刊：
影响因子：
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通讯作者：
JEWETT, RE
中科院分区：
文献类型：
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作者：
HOLTZMAN, S;JEWETT, RE
The effects ofd-amphetamine on food and water intake and brain monoamine concentrations in rats that had been deprived of food and water for 24 h were compared with those of two MAO inhibitors: tranylcypromine which has prominent amphetamine-like activity; and, pargyline which does not. All drugs produced dose-related depressions of food and water intake. The anorexic effects of the MAO inhibitors were correlated, over a 16-fold dose range, with elevated levels of norepinephrine, dopamine and serotonin. The anorexic effect ofd-amphetamine was blocked byα-methyltyrosine, an inhibitor of catecholamine synthesis.α-Methyltyrosine failed to block the depression of food and water intake caused by the MAO inhibitors, although the rise in catecholamine levels was prevented. It was concluded that the mechanisms by whichd-amphetamine produces anorexia may differ from those of the MAO inhibitors. Central adrenergic mediation appears to play a role in the anorexic activity ofd-amphetamine, but may not be essential for the anorexic effect of tranylcypromine and pargyline.
